About BIOS
Led by Daniel F. Hanley, MD, the BIOS Clinical Trials Coordinating Center is an academic research organization (ARO; clinical trial data management center, imaging reading center, and enrollment center) within the Johns Hopkins School of Medicine Department of Neurology. Its focus is to provide multicenter management to clinical trials evaluating therapeutic, preventive, and diagnostic interventions. BIOS CTCC is disease-agnostic with unique expertise in the coordination and management of trials investigating rare diseases and disorders, acute neurologic ICU conditions, rehabilitation, pain management, and functional outcomes. Although BIOS CTCC originated in the Department of Neurology and still is embedded in that department, it has expanded beyond support for neurology trials.
Johns Hopkins University TIC
BIOS CTCC and the Johns Hopkins Institute for Clinical and Translational Research (ICTR) have been awarded a $24.5 million grant from the National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS) to continue as a Trial Innovation Center (TIC).
The goal of the TICs is to promote innovations in the efficiency and quality of NIH-funded trials. The centers are part of the NCATS Trial Innovation Network and will work with the national Clinical and Translational Science Awards Program, which funds a consortium of 64 medical research institutions in 31 states and the District of Columbia. The centers will help the institutions form a long-standing infrastructure for multicenter studies to be funded by NIH and other funding agencies.
- Early Outpatient COVID-19 Plasma Treatment Research Study (CSSC-004) Named Top 10 Clinical Research Achievement Awardee
Clinical Research Forum named the BIOS CTCC study Early Outpatient COVID-19 Plasma Treatment Research Study (CSSC-004) one of the Top 10 2023 Clinical Research Achievement Awardees. The Clinical Research Achievement Awards is sponsored by the Clinical Research Forum, and it honors those who demonstrate a commitment to excellence and innovation in clinical research. This awards… - Early Outpatient COVID-19 Plasma Treatment Research Study (CSSC-004) Named Finalist for the 2023 Clinical Research Achievement Awards
The Early Outpatient COVID-19 Plasma Treatment Research Study (CSSC-004) has been named a finalist for the 2023 Clinical Research Achievement Awards. The Clinical Research Achievement Awards is sponsored by the Clinical Research Forum, and it honors those who demonstrate a commitment to excellence and innovation in clinical research. This awards program seeks to recognize research… - BIOS Awards 2022 Ann Dana Kusch Predoctoral Fellowship in Clinical Research and Innovation
The Johns Hopkins University Division of Brain Injury Outcomes (BIOS) is pleased to announce the 2022 recipient of the Ann Dana Kusch Predoctoral Fellowship in Clinical Research and Innovation: Paul Ryu. Funding to establish the fellowship was awarded in late 2020 by the Kusch and Molbert families in honor of their mother, Ann Dana Kusch,…
Recent Publications
Early outpatient treatment for Covid-19 with convalescent plasma.
Sullivan DJ, Gebo KA, Shoham S, et al. N Engl J Med. 2022;386(18):1700-1711. >Read our summary of the NEJM article
Using gamification to enhance clinical trial start-up activities.
Lane K, Majkowski R, Gruber J, et al. J Clin Transl Sci. 2022;6(1):e75.
Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume.
Sharrock MF, Mould WA, Hildreth M, et al. J Neuroimaging. 2022;32(5):968-976.
Early hyperchloremia is independently associated with death or disability in patients with intracerebral hemorrhage.
Qureshi AI, Huang W, Hanley DF, et al. Neurocrit Care. 2022;37(2):487-496.