Developing Therapies that Change People's Lives

Brain Injury Outcomes

Johns Hopkins University
1550 Orleans Street
CRB-II, 3M50 South
Baltimore, MD 21231 USA
Office:   (410) 614-6996
Fax: (410) 502-7869
 
24-Hr: (410) 736-1368

Our Latest Clinical Trials

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  • HU Prevent is a multicenter placebo-controlled clinical trial of hydroxyurea in children with sickle cell disease. The goal is to determine if hydroxyurea can prevent brain injury and stroke. BIOS is the national coordinating center for this trial conducted at 25 clinical sites.
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    • Active
    • Stroke
  • CLEAR-III is an international 500-patient randomized clinical trial evaluating thrombolysis vs. medical management alone in the treatment of intraventricular hemorrhage. With 75 hospitals participating, enrollment is expected to complete in late 2014.
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    • Active
    • Stroke
  • MISTIE-III is a 500-patient, international multicenter clinical trial launched in 2013 to confirm the safety and long-term efficacy of thrombolysis in the treatment of intracerebral hemorrhage (ICH). The 5-year trial is funded by NINDS and launched in 2013. Up to 100 of the top stroke centers across the world are expected to participate.
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    • Active
    • Stroke
  • EQUIGEN is composed of two bioequivalency trials. The EQUIGEN Chronic Dose trial is comparing two disparate generics of lamotrigine. The EQUIGEN Single Dose trial is comparing brand lamotrigine with two disparate generics of lamotrigine for patients with epilepsy. BIOS serves as the Coordinating Center for both trials.
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    • Active
    • Epilepsy
  • SMARTS is a study conducted by Dr. John Krakauer exploring how the brain changes over the first year following a stroke. We are using several non-invasive techniques, including MRI, transcranial magnetic stimulation and measures of arm movement to learn more about how individuals recover from stroke.
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    • Active
    • Stroke
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