Enrollment Has Reached 500

About VICTAS

VICTAS is a clinical trial for hospitalized patients with sepsis, a life-threatening condition caused by a severe infection. Sepsis occurs when the body releases so much of certain chemicals into the bloodstream to fight the infection that it causes an overwhelming inflammatory response throughout the body. This reaction then damages major organs and tissues. Someone with sepsis is critically ill and they will commonly have a fever, a fast heart rate, a fast respiration rate and confusion but other symptoms of the infection may also be present. Sepsis is usually treated in an intensive care unit and patients may need oxygen or mechanical ventilation (an artificial lung machine), medications to raise their low blood pressure, or dialysis to remove toxins from their blood. There is a significant risk of death in sepsis patients so new ways of treating it are badly needed.

Sepsis is usually treated with antibiotics and intravenous fluids. Certain medications, such as “anti-inflammatory” steroids like hydrocortisone, have been tested many times. Recently, a researcher reported that a combination of medications may be more effective than any of them by itself. They reported that injecting high doses of vitamin C in combination with thiamine (vitamin B1) and hydrocortisone reduces the damage to major organs and increases the likelihood of surviving a severe episode of sepsis. These therapies are experimental and have not been tested in large numbers of patients nor approved by the Food & Drug Administration (FDA). So, doctors do not know for sure that these therapies work or that they are safe enough to be used in large numbers of people. Early results look promising, but doctors must first perform a type of research called a clinical trial in order to collect data from lots of people before they can know for sure.

VICTAS is a clinical trial to test the combination of Vitamin C, thiamine and hydrocortisone for the treatment of sepsis.. It will be conducted across 30 to 40 major academic medical centers in the United States and will enroll at least 500 patients. All patients in the clinical trial will receive the regular best intensive care available for sepsis, and half of the patients will additionally receive vitamin C, thiamine and hydrocortisone. By testing a large number of patients, the doctors can then see if the group of patients that got the combination of medications did better than the group that did not.

These drugs will be given via an IV every six hours for a total of 96 hours. The doctors participating in this trial are located in the ER and ICU departments at several large hospitals across the United States. They will be collecting information about the use of vasopressors (drugs that increase blood pressure), respiratory support (treatments to aid breathing) and the status of the patients at 30 days and up to one year after treatment. Patients must be adults, non-pregnant, and meet certain requirements to be in the trial so that the doctors can do a proper comparison between the two groups.

Currently, clinical sites are being activated and the VICTAS trial has started to enroll subjects. More information and updates about this clinical trial will be posted here and at clinicaltrials.gov.

VICTAS Activated Sites

Site	Principal Investigator	Contact
Baystate Health Springfield, Massachusetts 1199	Steingrub, Jay	Thornton-Thompson, Sherell <Sherell.thornton-thompson@baystatehealth.org>
Bon Secours Richmond, Virginia 85008	Price, Katherine	Dickson, Lisa <lisa_dickson@bshsi.org>
Christiana Care Newark, Delaware 19718	Barrett, Matthew	Knox, Jennifer <Jknox@christianacare.org>
Cleveland Clinic Cleveland, Ohio 44195	Hite, Robert Duncan	Hastings, Andrei <hastina@ccf.org>
David Geffen School of Medicine at UCLA Los Angeles, California 30322	Qadir, Nida	Chang, Steven <sychang@mednet.ucla.edu>
Denver Health Denver, Colorado 80204	Haukoos, Jason	Cupelo, Alicia <alicia.cupelo@dhha.org>
Duke University Durham, North Carolina 90024	Bartz, Raquel	Sweeney, Katherine <katherine.sweeney@dm.duke.edu>
Emory St Joseph Hospital Atlanta, Georgia 30342	McBride, Mary	Sonya Mathewson <sbmathe@emory.edu>
Emory University Hospital Atlanta, Georgia 84112	Nugent, Kate	Christine Spainhour <christine.spainhour@emory.edu> Katherine Nugent <katherine.lyn.nugent@emory.edu>
Grady Hospital Atlanta, Georgia 30303	Sevransky, Jonathan	Lovie Negrin <lovienegrin@emory.edu> Carmen Polito <CPOLITO@emory.edu>
Hennepin County Medical Center Minneapolis, Minnesota 48202	Puskarich, Michael	Prekker, Matthew <matthew.prekker@hcmed.org>
Henry Ford Health System Detroit, Michigan 27710	Rivers, Emanuel	Jaehne, Anja Kathrin <AJaehne2@hfhs.org>
Intermountain Medical Center Murray, Utah 84157	Brown, Samuel	Aston, Valerie <valerie.aston@imail.org> Weaver, Lisa <lisa.weaver@hsc.utah.edu>
Johns Hopkins Bayview Baltimore, Maryland 06511	Hager, David	Arciaga, Zachary <zarciag1@jhmi.edu>
Johns Hopkins Hospital Baltimore, Maryland 21287	Hinson, Jeremiah	Erin Ricketts <ericket2@jhmi.edu> Jeremiah Hinson <jeremiah.s.hinson@jhmi.edu>
Louisiana State University New Orleans, Louisiana 70112	Janz, David	Vonderhaar, Derek <dvonde@lsuhsc.edu> Romaine, Connie <cromai@lsuhsc.edu>
Maricopa Integrated Health System Phoenix, Arizona 80045	LoVecchio, Frank	Mulrow, Mary <mary.mulrow@mihs.org>
Mayo Clinic Rochester, Minnesota 55902	CLEMENTS, CASEY	Gajic, Ongen <Gajic.Ognjen@mayo.edu>
Medical University of South Carolina Charleston, South Carolina 19107	Goodwin, Andrew	Warden, Ashley <jonesash@musc.edu>
Medstar Washington Hospital Center Washington DC, 20010	Goyal, Munish	Gadgil, Rucha <rucha.gadgil@medstar.net>
Memorial Sloan Kettering Cancer Center New York, New York 10065	Kostelecky, Natalie	Pastores, Stephen M. <pastores@mskcc.org>
Montefiore Medical Center Moses Bronx, New York 10467	Gong, Michelle	Ceusters, Daniel <dceuster@montefiore.org>
Montefiore Medical Center Weiler	Gong, Michelle	Ceusters, Daniel <dceuster@montefiore.org>
Ohio State University Wexner Medical Center Columbus, Ohio 45241	Exline, Matthew	Terndrup, Thomas <Thomas.Terndrup@osumc.edu>
Oregon Health Sciences University Portland, Oregon 27157	Khan, Akram	Pinkert, Vincent <pinkert@ohsu.edu> Benchbani, Hanna <benchban@ohsu.edu>
Piedmont Healthcare Atlanta, Georgia 30078	Case, Chad	Wilkins, Elizabeth <elizabeth.wilkins@piedmont.org>
Sentara Healthcare / Eastern Virginia Norfolk, Virginia 23507	Hooper, Michael	Counselman, Francis
Stanford University Stanford, California 21201	Quinn, James	Mann, Rosen <rka@stanford.edu> Wilson, Jenny <jennyqwilson@stanford.du>
Temple University Philadelphia, Pennsylvania 29425	Gentile, Nina	Marchetti, Nathaniel <nathaniel.marchetti@tuhs.temple.edu> Reimer, Hannah <hannah.reimer@tuhs.temple.edu>
Thomas Jefferson University Philadelphia, Pennsylvania 21224	Gaieski, David	Baram, Michael <Michael.Baram@jefferson.edu>
University of Arizona Tuscon, Arizona 85724	Mosier, Jarrod	Campbell, Elizabeth <bsalvag@email.arizona.edu>
University of Cincinnati Physicians Company Cincinnati, Ohio 23114	Huddock, Kristen	Studer, Autumn <studeran@ucmail.uc.edu>
University of Colorado Denver Denver, Colorado 19140	Ginde, Adit	Finck, Lani <lani.finck@ucdenver.edu>
University of Florida Jacksonville Jacksonville, Florida 32209	Guirgis, Faheem	Futch, Tasha <Tasha.Futch@jax.ufl.edu>
University of Maryland School of Medicine Baltimore, Maryland 55415	Wilkerson, R. Gentry	McCurdy, Michael <drmccurdy@gmail.com>
University of Michigan Ann Arbor, Michigan 48109	Pauline Park	McDonough, Kelli <kellimcd@med.umich.edu> Hanna, Sinan <sinanh@med.umich.edu>
University of Nebraska Medical Center Lincoln, Nebraska 68105	Barksdale, Aaron	Kalim, Daniel <dkalinj@unmc.edu>
University of Pennsylvania Health System Hospital Philadelphia, Pennsylvania 19104	Meyer, Nuala	Greenwood, John <John.Greenwood@uphs.upenn.edu>
University of Utah Salt Lake City, Utah 37235	Harris, Estelle	Plante, Amber <amber.plante@hsc.utah.edu> Weaver, Lisa <lisa.weaver@hsc.utah.edu>
Vanderbilt University Nashville, Tennessee 97239	Self, Wesley	Semler, Matthew <matthew.w.semler@vanderbilt.edu>
Virginia Commonwealth University Richmond, Virginia 23298	Fowler, Alpha	Puckett, Laura <laura.puckett@vcuhealth.org> Narron, Kyle <kyle.narron@vcuhelth.org>
Wake Forest University Winston Salem, North Carolina 43210	Files, D. Clark	Smith, Lane <lmsmith@wakehealth.edu>
Yale New Haven Hospital New Haven, Connecticut 94304	Belsky, Justin	Siner, Jonathan <jonathan.siner@yale.edu>

VICTAS Site Map