Welcome our newly activated site in February: Memorial Sloan Kettering Cancer Center and Piedmont Healthcare

Active Sites
29

Screened
1147

Enrolled
227

* The numbers will be updated weekly. Last update: Mar 19, 2019

About VICTAS

VICTAS TrialVICTAS is a clinical trial for hospitalized patients with sepsis, a life-threatening condition caused by a severe infection. Sepsis occurs when the body releases so much of certain chemicals into the bloodstream to fight the infection that it causes an overwhelming inflammatory response throughout the body. This reaction then damages major organs and tissues. Someone with sepsis is critically ill and they will commonly have a fever, a fast heart rate, a fast respiration rate and confusion but other symptoms of the infection may also be present. Sepsis is usually treated in an intensive care unit and patients may need oxygen or mechanical ventilation (an artificial lung machine), medications to raise their low blood pressure, or dialysis to remove toxins from their blood. There is a significant risk of death in sepsis patients so new ways of treating it are badly needed.

Sepsis is usually treated with antibiotics and intravenous fluids. Certain medications, such as “anti-inflammatory” steroids like hydrocortisone, have been tested many times. Recently, a researcher reported that a combination of medications may be more effective than any of them by itself. They reported that injecting high doses of vitamin C in combination with thiamine (vitamin B1) and hydrocortisone reduces the damage to major organs and increases the likelihood of surviving a severe episode of sepsis. These therapies are experimental and have not been tested in large numbers of patients nor approved by the Food & Drug Administration (FDA). So, doctors do not know for sure that these therapies work or that they are safe enough to be used in large numbers of people. Early results look promising, but doctors must first perform a type of research called a clinical trial in order to collect data from lots of people before they can know for sure.

VICTAS is a clinical trial to test the combination of Vitamin C, thiamine and hydrocortisone for the treatment of sepsis.. It will be conducted across 30 to 40 major academic medical centers in the United States and will enroll at least 500 patients. All patients in the clinical trial will receive the regular best intensive care available for sepsis, and half of the patients will additionally receive vitamin C, thiamine and hydrocortisone. By testing a large number of patients, the doctors can then see if the group of patients that got the combination of medications did better than the group that did not.

These drugs will be given via an IV every six hours for a total of 96 hours. The doctors participating in this trial are located in the ER and ICU departments at several large hospitals across the United States. They will be collecting information about the use of vasopressors (drugs that increase blood pressure), respiratory support (treatments to aid breathing) and the status of the patients at 30 days and up to one year after treatment. Patients must be adults, non-pregnant, and meet certain requirements to be in the trial so that the doctors can do a proper comparison between the two groups.

Currently, clinical sites are being activated and the VICTAS trial has started to enroll subjects. More information and updates about this clinical trial will be posted here and at clinicaltrials.gov.

VICTAS Activated Sites

Site Principal Investigator Contact
Bon Secours
Richmond, Virginia 85008
Price, Katherine Dickson, Lisa <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Cleveland Clinic
Cleveland, Ohio 44195
Hite, Robert Duncan Hastings, Andrei <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Denver Health
Denver, Colorado 80204
Haukoos, Jason Cupelo, Alicia <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Emory St Joseph Hospital
Atlanta, Georgia 30342
Larry Busse Sonya Mathewson <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Busse, Larry <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Emory University Hospital
Atlanta, Georgia 84112
Nugent, Kate Christine Spainhour <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Katherine Nugent <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Grady Hospital
Atlanta, Georgia 30303
Carmen Polito Lovie Negrin <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Polito, Carmen <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Hennepin County Medical Center
Minneapolis, Minnesota 48202
Puskarich, Michael Prekker, Matthew <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Henry Ford Health System
Detroit, Michigan 27710
Rivers, Emanuel Jaehne, Anja Kathrin <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Intermountain Medical Center
Murray, Utah 84157
Brown, Samuel Aston, Valerie <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Weaver, Lisa <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Johns Hopkins Bayview Medical Center
Baltimore, Maryland 21224
Hager, David Erin Ricketts <This email address is being protected from spambots. You need JavaScript enabled to view it.>
David Hager <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Johns Hopkins Hospital
Baltimore, Maryland 21287
Hinson, Jeremiah Erin Ricketts <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Jeremiah Hinson <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Louisiana State University
New Orleans, Louisiana 70112
Janz, David Vonderhaar, Derek <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Romaine, Connie <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Maricopa Integrated Health System
Phoenix, Arizona 80045
LoVecchio, Frank Mulrow, Mary <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Mayo Clinic
Rochester, Minnesota 55902
Clements, Casey Gajic, Ongen <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Medical University of South Carolina
Charleston, South Carolina 19107
Goodwin, Andrew Warden, Ashley <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Montefiore Medical Center
Bronx, New York 10467
Gong, Michelle Ceusters, Daniel <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Oregon Health Sciences University
Portland, Oregon 27157
Khan, Akram Pinkert, Vincent <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Benchbani, Hanna <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Piedmont Healthcare
Atlanta, Georgia 30078
   
Sentara Healthcare / Eastern Virginia
Norfolk, Virginia 23507
Hooper, Michael Hooper, Michael <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Jennifer F May <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Stanford University
Stanford, California 21201
Quinn, James Mann, Rosen <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Wilson, Jenny <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Temple University
Philadelphia, Pennsylvania 29425
Gentile, Nina Marchetti, Nathaniel <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Reimer, Hannah <This email address is being protected from spambots. You need JavaScript enabled to view it.>
University of Colorado Denver
Denver, Colorado 19140
Ginde, Adit Finck, Lani <This email address is being protected from spambots. You need JavaScript enabled to view it.>
University of Florida Jacksonville
Jacksonville, Florida 32209
Guirgis, Faheem Futch, Tasha <This email address is being protected from spambots. You need JavaScript enabled to view it.>
University of Nebraska Medical Center
Lincoln, Nebraska 68105
Barksdale, Aaron Kalim, Daniel <This email address is being protected from spambots. You need JavaScript enabled to view it.>
University of Utah
Salt Lake City, Utah 37235
Harris, Estelle Plante, Amber <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Weaver, Lisa <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Vanderbilt University
Nashville, Tennessee 97239
Self, Wesley Semler, Matthew <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Self, Wesley <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Virginia Commonwealth University
Richmond, Virginia 23298
Fowler, Alpha Puckett, Laura <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Narron, Kyle <This email address is being protected from spambots. You need JavaScript enabled to view it.>
Yale New Haven Hospital
New Haven, Connecticut 94304
Belsky, Justin Siner, Jonathan <This email address is being protected from spambots. You need JavaScript enabled to view it.>

VICTAS Site Map