Earlier this month, on April 3, PI: Alan Hoffer and Coordinator: Val Cwiklinski at Case Western Reserve University Hospital enrolled the last MISTIE-ICES subject, therefore closing the trial to enrollments! The MISTIE-ICES Trial opened in mid-2008 and has since enrolled 20 subjects across five centers: Barrow Neurological Institute, Case Western Reserve University Hospital, University of California, Los Angeles, University of California, San Diego and the University of Pittsburgh Medical Center.
The MISTIE-ICES Trial is the 3rdtier in Stage I of the MISTIE Trial. The purpose of the MISTIE-ICES Trial is to determine the safety of using either endoscopic surgery (ICES) or a combination of minimally invasive surgery and clot lysis with rt-PA (MISTIE) to remove intracerebral hemorrhage. The ICES arm is led by Drs. Paul Vespa and Neil Martin at the University of California, Los Angeles and Dr. Dan Hanley at Johns Hopkins University.