Does faster clot removal in ICH give better patient outcomes?

115 Sites to Qualify:
90 Sites to Activate:
500 Participants to Enroll:

CANCELED: January's MISTIE III Monthly Webinar

Dear Teams,

In light of the holiday season, we have decided to cancel our January 2nd MISTIE III Monthly Webinar.  Please join us when we meet again on Tuesday, February 6th, 8am and 2pm.


Thank you and from all of us at BIOS, we wish you joy and peace this holiday season!

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CLEAR IV Webinar Recording Now Available!

Hello Everyone,

       Here is a video link to Dr. Daniel F. Hanley's webinar presentation on the CLEAR IV trial, which took place on November 7th, 2017. The video includes a comprehensive overview of the design, justification, and science behind the CLEAR IV trial. If you have any questions, feel free to contact myself (This email address is being protected from spambots. You need JavaScript enabled to view it.), Amanda Bistran-Hall (This email address is being protected from spambots. You need JavaScript enabled to view it.), or any BIOS team member. Thank you and enjoy!

- Hasan



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M3 November Monthly Webinar: CLEAR IV Takeover

Learn the next steps as we plan to embark on the CLEAR IV Trial!


Tuesday, November 7th at 8am and 2pm EST.


You must be registered to attend.


8am: https://attendee.gotowebinar.com/register/1383745654482714115



2pm: https://attendee.gotowebinar.com/register/7592602054626842115


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MISTIE 3 in the final stretch!

The MISTIE III clinical trial, evaluating catheter-delivered thrombolysis for the treatment of intracerebral hemorrhage, is on track to complete enrollment in mid-2017.  The 400th patient, out of 500 planned, was enrolled on 01-November!

Currently, there are 62 active sites which have screened over 15,000 subjects. There were 173 patients enrolled over the trailing twelve months, for an average of 14.4 patients randomized each month, albeit there is notable month-to-month variability with enrollment generally being higher in the winter months. Extrapolating, that suggests that enrollment should complete by June, which would be two months ahead of plan. Follow-up of the last enrolling patient should be complete 12 months later.

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Save the Date: MISTIE III Quarterly Refresher

Our next Quarterly Refresher will be held:


Thursday, November 10, 2016 

10am - 2pm EST


Registration link: https://attendee.gotowebinar.com/rt/8885372643073065986 

Once registered, details of the webinar will be e-mailed to you.


Please contact Amanda (This email address is being protected from spambots. You need JavaScript enabled to view it.) with any questions.


Future Refreshers:

February 9, 2017

May 11, 2017

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Brain Injury Outcomes

Johns Hopkins University
1550 Orleans Street
CRB-II, 3M50 South
Baltimore, MD 21231 USA
Office:   (410) 614-6996
Fax: (410) 502-7869
24-Hr: (410) 736-1368