Intraventricular Hemorrhage Therapeutics Registry

Having now completed enrollment in the CLEAR-III clinical trial, we are launching a clinical registry to track worldwide adoption of the therapy and techniques that were evaluated during the phase III clinical trial. It is hoped that this registry will help stroke researchers and scientists gain valuable information about the use of intraventricular thrombolytic therapy as it is generalized to community hospitals and specialized stroke centers around the world, many of which may not have participated in the CLEAR III clinical trial.

Neurosurgeons, neurologists and neurointensivists worldwide who are working in the field of hemorrhagic stroke are invited to apply for participation. This registry does not collect any personally-identifiable patient health information (PHI) and therefore should not require a HIPAA release. Cases are identified only by a unique sequential number, subject age (if under 90 years old), gender and race. There are no patient-related dates being collected. This registry has been approved by Johns Hopkins University Institutional Review Board (IRB00059240, 23-Jan-2015) as an international clinical research registry; you should check with your local IRB/EC to see if any local approval may be needed.

Hypothesis:  Intraventricular thrombolysis for Intraventricular Hemorrhage can be conducted with comparable efficacy and safety in a non-clinical trial setting as compared to CLEAR-III.

Inclusion Criteria: Adults (at least 18 years old) being treated for spontaneous intraventricular hemorrhage (IVH) with obstruction of 3rd and/or 4th ventricle(s). Subjects with structural vascular brain lesions (tumor, moyamoya, AVM, aneurysm, etc.) should be excluded.

Coordinating Investigator:  Wendy Ziai, MD of Johns Hopkins Medicine, with the support of Brain Injury Outcomes and Emissary International.

TO JOIN THE REGISTRY, you must complete the application form (click here, or if you are already registered on this site, This email address is being protected from spambots. You need JavaScript enabled to view it.) and be approved, after which we will mail you a username and password for accessing the application, which you will soon be able to download from the GOOGLE and iTUNES stores as native mobile apps.

TO ACCESS VIA A WEB BROWSER, you can click here to load it in your browser. If you do this from your phone, you can then save it as a "web app" on your phone. From Safari on the iPhone, click the SHARE button, then select ADD TO HOME SCREEN.

 

©Copyright 2015 Emissary International LLC on behalf of Johns Hopkins University
The design, programming, content and layout of the IVH Therapeutics App is proprietary.
Authorization for use in this project is granted only to approved participating investigators.

Enrollment Summary as of 15-Aug-14: 

  • Total Enrollment -  460
    • International - 118
      • Israel - 36
      • Germany - 34
      • Spain - 14
      • Canada - 8
      • Switzerland - 4
      • Brazil - 4
      • United Kingdom - 6
      • Hungary - 12
    • USA - 342

August - 2014

Congratulations to Dr. Sayona John (PI), Fumie Kita (coordinator), and the rest of the team at Rush University for their 24th enrollment on 8-15-2014 (the trial's 460th enrollment).

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 15th enrollment on 8-11-2014 (the trial's 459th enrollment).

Congratulations to Dr. Jody Leonardo (PI), Beth Cahill (coordinator), and the rest of the team at the University of Buffalo for their 7th enrollment on 8-6-2014 (the trial's 458th enrollment).

Congratulations to Dr. Qaisar Shah (PI), Patricia Bussinger (coordinator), and the rest of the team at Abington Memorial Hospital for their 4th enrollment on 8-2-2014 (the trial's 457th enrollment).

July - 2014

Congratulations to Dr. Diederik Bulters (PI), Martina Brown (coordinator), and the rest of the team at the University of Southampton Hospital for their 5th enrollment on 7-30-2014 (the trial's 456th enrollment).

Congratulations to Dr. Guy Rosenthal (PI), Alex Furmanov (coordinator), and the rest of the team at Hadassah Hebrew University Hospital for their 7th enrollment on 7-22-2014 (the trial's 455th enrollment).

Congratulations to Dr. Paul Vespa (PI), Courtney Real (coordinator), and the rest of the team at UCLA for their 7th enrollment on 7-13-2014 (the trial's 454th enrollment).

Congratulations to Dr. Thomas Mirsen (PI), Cory Hackmyer (coordinator), and the rest of the team at Cooper University Hospital for their 2nd enrollment on 7-12-2014 (the trial's 453rd enrollment).

Congratulations to Dr. Julian Boesel (PI), Perdita Beck (coordinator), and the rest of the team at the University of Heidelberg for their 10th enrollment on 7-11-2014 (the trial's 452nd enrollment).

Congratulations to Dr. Sven Poli (PI), Julia Zeller (coordinator), and the rest of the team at the University of Tubingen for their 2nd enrollment on 7-2-2014 (the trial's 451st enrollment).

June - 2014

Congratulations to Dr. Francois Aldrich (PI), Charlene Aldrich (coordinator), and the rest of the team at the University of Maryland for their 18th enrollment on 6-9-2014 (the trial's 450th enrollment).

Congratulations to Dr. Sven Poli (PI), Julia Zeller (coordinator), and the rest of the team at the University of Tubingen for their 1st enrollment on 6-3-2014 (the trial's 449th enrollment).

Congratulations to Dr. Safdar Ansari (PI), Julie Martinez (coordinator), and the rest of the team at the University of Utah for their 14th enrollment on 6-3-2014 (the trial's 448th enrollment).

May - 2014

Congratulations to Dr. Paul Camarata (PI), Jason Gorup (coordinator), and the rest of the team at Kansas University Medical Center for their 4th enrollment on 5-16-2014 (the trial's 446th enrollment).

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 14th enrollment on 5-15-2014 (the trial's 445th enrollment).

Congratulations to Dr. Carsten Hobohm (PI), Rita Lachmund, Daniela Urban (coordinators), and the rest of the team at the University of Leipzig for their 5th enrollment on 5-14-2014 (the trial's 444th enrollment).

Congratulations to Dr. Nicole Gonzales (PI), Chad Tremont (coordinator), and the rest of the team at the University of Texas, Houston for their 21st enrollment on 5-11-2014 (the trial's 443rd enrollment).

April - 2014

Congratulations to Dr. Francois Aldrich (PI), Charlene Aldrich (coordinator), and the rest of the team at University of Maryland for their 17th enrollment on 4-25-2014 (the trial's 442nd enrollment).

Congratulations to Dr. Alan Hoffer (PI), Valerie Cwiklinski (coordinator), and the rest of the team at Case-Western Reserve University Hospital for their 7th enrollment on 4-23-2014 (the trial's 441st enrollment).

Congratulations to Dr. David Antezana (PI), Monica Rodriguez (coordinator), and the rest of the team at Providence Stroke Center for their 4th enrollment on 4-19-2014 (the trial's 440th enrollment).

Congratulations to Dr. Sagi Harnof (PI), Nina Lehvar (coordinator), and the rest of the team at Sheba Medical Center for their 23rd enrollment on 4-13-2014 (the trial's 439th enrollment).

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 13th enrollment on 4-7-2014 (the trial's 438th enrollment).

Congratulations to Dr. Jack Jallo (PI), Melissa Witt (coordinator), and the rest of the team at Thomas Jefferson University Hospital for their 12th enrollment on 4-6-2014 (the trial's 437th enrollment).

Congratulations to Dr. Thomas Kerz (PI) and the rest of the team at the University of Mainz for their 7th enrollment on 4-1-2014 (the trial's 436th enrollment).

March - 2014

Congratulations to Dr. Wendy Ziai (PI), Mirinda White (coordinator), and the rest of the team at Johns Hopkins Hospital for their 16th enrollment on 3-31-2014 (the trial's 435th enrollment).

Congratulations to Dr. Kevin Cockroft (PI), Deborah Hoffman (coordinator), and the rest of the team at Penn State Hershey Medical Center for their 6th enrollment on 3-30-2014 (the trial's 434th enrollment).

Congratulations to Dr. Sagi Harnof (PI), Nina Lehvar (coordinator), and the rest of the team at Sheba Medical Center for their 22nd enrollment on 3-30-2014 (the trial's 433rd enrollment).

Congratulations to Dr. Chitra Venkatasubramanian (PI), Madelline Garcia (coordinator), and the rest of the team at the Stanford University for their 6th enrollment on 3-29-2014 (the trial's 432nd enrollment).

Congratulations to Dr. Safdar Ansari (PI), Julie Martinez (coordinator), and the rest of the team at the University of Utah for their 13th enrollment on 3-28-2014 (the trial's 431st enrollment).

Congratulations to Dr. Guy Rosenthal (PI), Alex Furmanov (coordinator), and the rest of the team at Hadassah Hebrew University for their 6th enrollment on 3-25-2014 (the trial's 430th enrollment).

Congratulations to Dr. David Greer (PI), Janet Halliday (coordinator), and the rest of the team at Yale University for their 3rd enrollment on 3-20-2014 (the trial's 429th enrollment).

Congratulations to Dr. Sachin Agarwal (PI), Cristina Falo (coordinator), and the rest of the team at Columbia University for their 5th and 6th enrollments on 3-13-2014 and 3-14-2014 (the trial's 427th and 428th enrollments).

Congratulations to Dr. Laszlo Szapary (PI), Peter Bukovics (coordinator), and the rest of the team at the University of Pecs for their 4th enrollment on 3-8-2014 (the trial's 426th enrollment).

Congratulations to Dr. Jody Leonardo (PI), Mary Hartney (coordinator), and the rest of the team at the University of Buffalo for their 6th enrollment on 3-7-2014 (the trial's 425th enrollment).

Congratulations to Dr. Inam Kureshi (PI), Sara Jasak (coordinator), and the rest of the team at Hartford Hospital for their 5th enrollment on 3-6-2014 (the trial's 424th enrollment).

Congratulations to Dr. Julian Boesel (PI), Perdita Beck (coordinator), and the rest of the team at the University of Heidelberg for their 9th enrollment on 3-4-2014 (the trial's 423rd enrollment).

February - 2014

Congratulations to Dr. Opeolu Adeoye (PI), Becky Reinert (coordinator), and the rest of the team at the University of Cincinnati for their 11th enrollment on 2-27-2014 (the trial's 422nd enrollment).

Congratulations to Dr. Paul Camarata (PI), Jason Gorup (coordinator), and the rest of the team at Kansas University Medical Center for their 3rd enrollment on 2-26-2014 (the trial's 421st enrollment).

Congratulations to Dr. Sagi Harnof (PI), Nina Lehvar (coordinator), and the rest of the team at Sheba Medical Center for their 20th and 21st enrollments on 2-23-2014 and 2-24-2014 (the trial's 419th and 420th enrollments).

Congratulations to Dr. Alan Hoffer (PI), Valerie Cwiklinski (coordinator), and the rest of the team at Case-Western Reserve University Hospital for their 6th enrollment on 2-21-2014 (the trial's 418th enrollment).

Congratulations to Dr. Laszlo Csiba (PI), Katalin Szabó (coordinator), and the rest of the team at The University of Debrecen for their 5th enrollment on 2-20-2014 (the trial's 417th enrollment).

Congratulations to Dr. Opeolu Adeoye (PI), Becky Reinert (coordinator), and the rest of the team at The University of Cincinnati for their 10th enrollment on 2-12-2014 (the trial's 416th enrollment).

January - 2014

Congratulations to Dr. Fernando Testai (PI), Maureen Hillmann (coordinator), and the rest of the team at The University of Illinois at Chicago for their 8th enrollment on 1-31-2014 (the trial's 415th enrollment).

Congratulations to Dr. Francois Aldrich (PI), Charlene Aldrich (coordinator), and the rest of the team at The University of Maryland for their 8th enrollment on 1-28-2014 (the trial's 414th enrollment).

Congratulations to Dr. Julian Boesel (PI), Perdita Beck (coordinator), and the rest of the team at The University of Heidelberg for their 8th enrollment on 1-24-2014 (the trial's 413th enrollment).

Congratulations to Dr. Wendy Ziai (PI), Mirinda White (coordinator), and the rest of the team at Johns Hopkins Hospital for their 15th enrollment on 1-22-2014 (the trial's 412th enrollment).

Congratulations to Dr. Katja Wartenberg (PI), Tobias Muller (Investigator), Karina Targan (coordinator), and the rest of the team at Thomas Jefferson University for their 8th enrollment on 1-22-2014 (the trial's 411th enrollment).

Congratulations to Dr. Jack Jallo (PI), Melissa Witt (coordinator), and the rest of the team at Thomas Jefferson University for their 11th enrollment on 1-16-2014 (the trial's 410th enrollment).

Congratulations to Dr. Hagen Huttner (PI), Dimitre Staykov (coordinator), and the rest of the team at The University of Erlangen for their 2nd enrollment on 1-16-2014 (the trial's 409th enrollment).

Congratulations to Dr. Opeolu Adeoye (PI), Becky Reinert (coordinator), and the rest of the team at The University of Cincinnati for their 9th enrollment on 1-16-2014 (the trial's 408th enrollment).

Congratulations to Dr. Julius Gene Latorre (PI), Iulia Movileanu (coordinator), and the rest of the team at SUNY Upstate Medical Center for their 4th enrollment on 1-14-2014 (the trial's 407th enrollment).

Congratulations to Dr. Guy Rosenthal (PI), Alex Furmanov (coordinator), and the rest of the team at Hadassah Hebrew University Hospital for their 5th enrollment on 1-7-2014 (the trial's 406th enrollment).

Congratulations to Dr. Francois Aldrich (PI), Charlene Aldrich (coordinator), and the rest of the team at the University of Maryland for their 15th enrollment on 1-7-2014 (the trial's 405th enrollment).

 

See prior year enrollments

The CLEAR-IVH trial, completed in 2008, was a phase-II feasibility and dose-finding trial conducted at 20 centers in the U.S., Canada, U.K. and Germany. There were 3 phases: Safety, CLEAR A and CLEAR B. The study enrolled 52 patients having a confirmed diagnosis of intraventricular hemorrhage (IVH) with third or fourth ventricle obstruction. Patients were given a thrombolytic, recombinant tissue plasminogen activator (tPA), via a extraventricular catheter (EVD) in one of three dosing regimens over a 3 day period. Results of the study were presented by Dr. Daniel Hanley of Johns Hopkins University, lead investigator, at the 2008 European Stroke Conference in Nice, France.

This study provided an early demonstration that treatment of IVH with catheter-delivered low-dose tPA can be safe and holds significant promise for becoming a safe, life-saving treatment for this devastating and usually lethal form of hemorrhagic stroke. In this relatively small group of IVH patients, 40% recovered to the point of living independently and 10% were completely normal with no deficits at the end of the 6-month follow-up period. The 30-day mortality rate was 15% compared to a typical rate of 80-85%.

The Intraventricular Hemorrhage Thrombolysis Trial was supported by grants (FD-R-001693 to Dr. Naff and Dr. Hanley) and (FD-R 002018 to Dr. Hanley and Dr. Rhoney) from the Office of Orphan Products Development, Food and Drug Administration. Dr. Naff received funding from the American Heart Association and funding from a research grant (FD-R-001693) from the Office of Orphan Products Development. Dr. Penelope Keyl received funding from a research grant (FD-R-001693) from the Office of Orphan Products Development. Karen Lane and Nichol McBee received funding from a research grant (FD-R-001693) from the Office of Orphan Products Development. Dr. Stanley Tuhrim received funding from a research grant (FD-R- 001693) from the Office of Orphan Products Development. Dr. Anthony Marmarou received funding from a research grant (FD-R-001693) from the Office of Orphan Products Development. Dr. Daniel Hanley is supported by grants U01NS062851 and RO1NS046309 from the National Institutes of Health/NINDS, grant 272-2007 from the Eleanor Naylor Dana Charitable Trust, the Jeffrey and Harriet Legum Endowment and materials grants from Genentech, Inc.

The study results established the optimal dosage, validated the dosing procedure and provided justification for launching the large phase-III trial, CLEAR-III in mid-2009.

Published in Stroke. 2011;42:3009-3016

 

Enrollment Summary as of 31-Dec-13:

  • Total Enrollment - 404
    • International - 102
      • Israel - 30
      • Germany - 25
      • Spain - 14
      • Canada - 8
      • Switzerland - 4
      • Brazil - 4
      • United Kingdom - 5
      • Hungary - 10
    • USA - 302

December - 2013

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 12th enrollment on 12-27-2013 (the trial's 404th enrollment).

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 11th enrollment on 12-23-2013 (the trial's 403rd enrollment).

Congratulations to Dr. Katja Wartenberg (PI), Karina Targan (coordinator), and the rest of the team at the University of Halle for their 7th enrollment on 12-17-2013 (the trial's 402nd enrollment).

Congratulations to Dr. Hagen Huttner (PI), Demitre Staykov (coordinator), and the rest of the team at the University of Erlangen for their 1st enrollment on 12-17-2013 (the trial's 401st enrollment).

Congratulations to Dr. David Ledoux (PI), Cletus Cheyuo (coordinator), and the rest of the team at Northshore Long Island for their 11th enrollment on 12-9-2013 (the trial's 400th enrollment).

Congratulations to Dr. Joan Marti-Fabregas (PI), Rebeca Marin Bueno(coordinator), and the rest of the team at Hospital de la Santa Creu i Sant Pau, Barcelona for their 2nd enrollment on 12-5-2013 (the trial's 399th enrollment).

Congratulations to Dr. Fuat Arikan (PI), Alba Peña Paris (coordinator), and the rest of the team at Vall d'Hebron University Hospital, Barcelona for their 7th enrollment on 12-5-2013 (the trial's 398th enrollment).

November - 2013

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 5th enrollment on 11-29-2013 (the trial's 397th enrollment).

Congratulations to Dr. Kevin Cockroft (PI), Deborah Hoffman (coordinator), and the rest of the team at Penn State Hershey Medical Center for their 5th enrollment on 11-27-2013 (the trial's 396th enrollment).

Congratulations to Dr. Alberto Torres Díaz (PI), Dr. Carlos Francisco Alarcón Alba (coordinator), and the rest of the team at Bellvitge Hospital, Barcelona for their 5th enrollment on 11-20-2013 (the trial's 395th enrollment).

Congratulations to Dr. David Ledoux (PI), Cletus Cheyuo (coordinator), and the rest of the team at NorthShore Long Island for their 10th enrollment on 11-17-2013 (the trial's 394th enrollment).

Congratulations to Dr. George Lopez (PI), Chad Tremont (coordinator), and the rest of the team at the University of Texas, Houston for their 20th enrollment on 11-17-2013 (the trial's 393rd enrollment).

Congratulations to Dr. Harold Adams (PI), Heena Olalde (coordinator), and the rest of the team at the University of Iowa for their 11th enrollment on 11-16-2013 (the trial's 392nd enrollment).

Congratulations to Dr. Qaisar Shah (PI), Karin Jonczak (coordinator), and the rest of the team at Abington Memorial Hospital for their 3rd enrollment on 11-13-2013 (the trial's 391st enrollment).

Congratulations to Dr. Harold Adams (PI), Heena Olalde (coordinator), and the rest of the team at the University of Iowa for their 10th enrollment on 11-12-2013 (the trial's 390th enrollment).

Congratulations to Dr. Laszlo Szapary (PI), Peter Bukovics (coordinator), and the rest of the team at the University of Pecs for their 3rd enrollment on 11-8-2013 (the trial's 389th enrollment).

October - 2013 

Congratulations to Dr. Kenneth Butcher (PI), Mahesh Kate (Sub-I), Leka Sivkumar (coordinator), and the rest of the team at the University of Alberta for their 5th enrollment on 10-29-2013 (the trial's 388th enrollment). 

Congratulations to Dr. Agnieszka Ardelt (PI), Cedric McKoy (coordinator), and the rest of the team at the University of Chicago for their 4th enrollment on 10-27-2013 (the trial's 387th enrollment). 

Congratulations to Dr. Jody Leonardo (PI), Mary Hartney (coordinator), and the rest of the team at the University of Buffalo for their 5th enrollment on 10-25-2013 (the trial's 386th enrollment). 

Congratulations to Dr. Francois Aldrich (PI), Charlene Aldrich (coordinator), and the rest of the team at the University of Maryland for their 14th enrollment on 10-21-2013 (the trial's 385th enrollment). 

Congratulations to Dr. Fernando Testai (PI), Maureen Hillman (coordinator), and the rest of the team at the University of Illinois, Chicago for their 7th enrollment on 10-16-2013 (the trial's 384th enrollment). 

Congratulations to Dr. Safdar Ansari (PI), Julie Martinez (coordinator), and the rest of the team at the University of Utah for their 12th enrollment on 10-16-2013 (the trial's 383rd enrollment). 

Congratulations to Dr. Francois Aldrich (PI), Charlene Aldrich (coordinator), and the rest of the team at the University of Maryland for their 13th enrollment on 10-12-2013 (the trial's 382nd enrollment). 

Congratulations to Dr. Ashis H. Tayal (PI), Melissa Tian (coordinator), and the rest of the team at Allegheny General Hospital for their 8th enrollment on 10-10-2013 (the trial's 381st enrollment). 

Congratulations to Dr. Fernando Testai (PI), Maureen Hillman (coordinator), and the rest of the team at Cedars-Sinai Medical Center for their 6th enrollment on 10-9-2013 (the trial's 380th enrollment). 

Congratulations to Dr. Asma Moheet (PI), Felice Lin (coordinator), and the rest of the team at Cedars-Sinai Medical Center for their 7th enrollment on 10-9-2013 (the trial's 379th enrollment). 

Congratulations to Dr. Inam Kureshi (PI), Sara Jasak (coordinator), and the rest of the team at Hartford Hospital for their 4th enrollment on 10-6-2013 (the trial's 378th enrollment). 

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at the University of Heidelberg for their 9th enrollment on 10-4-2013 (the trial's 377th enrollment). 

Congratulations to Dr. Julian Boesel (PI), Perdita Beck (coordinator), and the rest of the team at the University of Heidelberg for their 7th enrollment on 10-2-2013 (the trial's 376th enrollment). 

September - 2013

Congratulations to Dr. Jean-Louis Caron (PI), Esther Nanez (coordinator), and the rest of the team at the University of Chicago for their 12th enrollment on 9-30-2013 (the trial's 375th enrollment). 

Congratulations to Dr. Agnieszka Ardelt (PI), Cedric McKoy (coordinator), and the rest of the team at the University of Chicago for their 3rd enrollment on 9-26-2013 (the trial's 374th enrollment). 

Congratulations to Dr. J Mocco (PI), Chesney Oravec (coordinator), and the rest of the team at Vanderbilt University for their 2nd enrollment on 9-18-2013 (the trial's 373rd enrollment). 

Congratulations to Dr. Francois Aldrich (PI), Charlene Aldrich (coordinator), and the rest of the team at the University of Maryland for their 12th enrollment on 9-17-2013 (the trial's 372nd enrollment). 

Congratulations to Dr. Sayona John (PI), Fumie Kita (coordinator), and the rest of the team at Rush University for their 23rd enrollment on 9-14-2013 (the trial's 371st enrollment). 

Congratulations to Dr. David Seder (PI), Barbara McCrum (coordinator), and the rest of the team at Maine Medical Center for their 8th enrollment on 9-13-2013 (the trial's 370th enrollment). 

August - 2013

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 8th enrollment on 8-27-2013 (the trial's 369th enrollment). 

Congratulations to Dr. Inam Kureshi (PI), Sara Jasak (coordinator), and the rest of the team at Hartford Hospital for their 3rd enrollment on 8-23-2013 (the trial's 368th enrollment). 

Congratulations to Dr. Pal Barzo (PI), Eniko Fako (coordinator), and the rest of the team at the University of Szeged for their 3rd enrollment on 8-23-2013 (the trial's 367th enrollment). 

Congratulations to Dr. Qaisar A.Shah (PI), Karin Jonczak (coordinator), and the rest of the team at Abington Memorial Hospital for their 2nd enrollment on 8-12-2013 (the trial's 366th enrollment). 

Congratulations to Dr. David Seder (PI), Barbara McCrum (coordinator), and the rest of the team at Maine Medical Center for their 7th enrollment on 8-12-2013 (the trial's 365th enrollment). 

Congratulations to Dr. Sagi Harnof (PI), Nina Lehvar (coordinator), and the rest of the team at Chaim Sheba Medical Center for their 19th enrollment on 8-8-2013 (the trial's 364th enrollment). 

Congratulations to Dr. Wendy Ziai (PI), Mirinda White (coordinator), and the rest of the team at Johns Hopkins Hospital for their 14th enrollment on 8-4-2013 (the trial's 363rd enrollment). 

Congratulations to Dr. Thomas Kerz (PI), and the rest of the team at the University of Mainz for their 6th enrollment on 8-4-2013 (the trial's 362nd enrollment). 

Congratulations to Dr. Fernando Testai (PI), Maureen Hillman (coordinator), and the rest of the team at the University of Illinois at Chicago for their 5th enrollment on 8-1-2013 (the trial's 361st enrollment). 

July - 2013

Congratulations to Dr. David Ledoux (PI), Timothy White, Cletus Chuyo (coordinators), and the rest of the team at NorthShore Long Island for their 9th enrollment on 7-29-2013 (the trial's 360th enrollment). 

Congratulations to Dr. Kristi Tucker (PI), Sara Vaughan, (coordinator), and the rest of the team at Stanford University for their 4th enrollment on 7-25-2013 (the trial's 359th enrollment). 

Congratulations to Dr. Chitra Venkat (PI), Ryan Snider, (coordinator), and the rest of the team at Stanford University for their 5th enrollment on 7-19-2013 (the trial's 358th enrollment). 

Congratulations to Dr. George Lopez (PI), Chad Tremont, (coordinator), and the rest of the team at the University of Texas, Houston for their 19th enrollment on 7-18-2013 (the trial's 357th enrollment). 

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson, (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 7th enrollment on 7-15-2013 (the trial's 356th enrollment). 

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson, (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 6th enrollment on 7-10-2013 (the trial's 355th enrollment). 

Congratulations to Dr. E Francois Aldrich (PI), Charlene Aldrich, (coordinator), and the rest of the team at the University of Maryland for their 11th enrollment on 7-1-2013 (the trial's 354th enrollment). 

June - 2013

Congratulations to Dr. E Francois Aldrich (PI), Charlene Aldrich, (coordinator), and the rest of the team at the University of Maryland for their 10th enrollment on 6-27-2013 (the trial's 353rd enrollment). 

Congratulations to Dr. E Francois Aldrich (PI), Charlene Aldrich, (coordinator), and the rest of the team at the University of Maryland for their 9th enrollment on 6-10-2013 (the trial's 352nd enrollment). 

Congratulations to Dr. Opeolu Adeoye (PI), Becky Reinert, Carolyn Koenig (coordinators), and the rest of the team at the University of Cincinnati for their 8th enrollment on 6-2-2013 (the trial's 351st enrollment). 

May - 2013

Congratulations to Dr. George Lopez (PI), Chad Tremont, (coordinator), and the rest of the team at the University of Texas, Houston for their 18th enrollment on 5-15-2013 (the trial's 350th enrollment). 

Congratulations to Dr. David LeDoux (PI), Timothy White, (coordinator), and the rest of the team at NorthShore Long Island for their 8th enrollment on 5-13-2013 (the trial's 349th enrollment). 

Congratulations to Dr. Robert E. Hoesch (PI), Julie Martinez, (coordinator), and the rest of the team at the University of Utah for their 11th enrollment on 5-11-2013 (the trial's 348th enrollment). 

Congratulations to Dr. Guy Rosenthal (PI), Alex Furmanov, (coordinator), and the rest of the team at Hadassah Hebrew University Hospital for their 4th enrollment on 5-11-2013 (the trial's 347th enrollment). 

Congratulations to Dr. Alan Hoffer (PI), Valerie Cwiklinski, (coordinator), and the rest of the team at Case-Western Reserve University Hospital for their 5th enrollment on 5-8-2013 (the trial's 346th enrollment). 

Congratulations to Dr. Panayiotis Varelas (PI), Kathleen Mays-Wilson, (coordinator), and the rest of the team at Henry Ford Health System for their 13th enrollment on 5-6-2013 (the trial's 345th enrollment). 

Congratulations to Dr. Wendy Ziai (PI), Marinda White, (coordinator), and the rest of the team at Johns Hopkins Hospital for their 14th enrollment on 5-3-2013 (the trial's 344th enrollment). 

April - 2013

Congratulations to Dr. Wendy Ziai (PI), Marinda White, (coordinator), and the rest of the team at Johns Hopkins Hospital for their 13th enrollment on 4-20-2013 (the trial's 343rd enrollment). 

Congratulations to Dr. Katja Wartenberg (PI), Karina Targan, (coordinator), and the rest of the team at Johns Hopkins Hospital for their 6th enrollment on 4-19-2013 (the trial's 342nd enrollment). 

Congratulations to Dr. Wendy Ziai (PI), Marinda White, (coordinator), and the rest of the team at Johns Hopkins Hospital for their 12th enrollment on 4-11-2013 (the trial's 341st enrollment). 

Congratulations to Dr. Nevo Margalit (PI), Carmit Ben Harosh, (coordinator), and the rest of the team at Sourasky Medical Center for their 6th enrollment on 4-10-2013 (the trial's 340th enrollment). 

Congratulations to Dr. J Mocco (PI), Chesney Oravec, (coordinator), and the rest of the team at Vanderbilt University Medical Center for their 5th enrollment on 4-5-2013 (the trial's 339th enrollment). 

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson, (coordinator), and the rest of the team at University of Alabama at Birmingham for their 5th enrollment on 4-5-2013 (the trial's 338th enrollment). 

Congratulations to Dr. Julian Boesel (PI), Perdita Beck, (coordinator), and the rest of the team at University of Heidelberg for their 6th enrollment on 4-4-2013 (the trial's 337th enrollment). 

Congratulations to Dr. Pal Barzo (PI), Eniko Fako, (coordinator), and the rest of the team at University of Szeged for their 2nd enrollment on 4-2-2013 (the trial's 336th enrollment). 

March - 2013

Congratulations to Dr. Harold Adams (PI), Heena Olalde, (coordinator), and the rest of the team at University of Iowa for their 9th enrollment on 3-27-2013 (the trial's 335th enrollment). 

Congratulations to Dr. George Lopez (PI), Chad Tremont, (coordinator), and the rest of the team at University of Texas, Houston for their 17th enrollment on 3-25-2013 (the trial's 334th enrollment). 

Congratulations to Dr. David Antezana (PI), Monica Rodriguez, (coordinator), and the rest of the team at Providence Medical Center for their 3rd enrollment on 3-21-2013 (the trial's 333rd enrollment). 

Congratulations to Dr. Sayona John (PI), Terry Cole, Fumie Kita (coordinators), and the rest of the team at Rush University for their 22nd enrollment on 3-21-2013 (the trial's 332nd enrollment). 

Congratulations to Dr. Carsten Hobohm (PI), Daniela Urban, (coordinator), and the rest of the team at the University of Leipzig for their 4th enrollment on 3-21-2013 (the trial's 331st enrollment). 

Congratulations to Dr. Laszlo Csiba (PI), Katalin Szabó, (coordinator), and the rest of the team at the University of Debrecen for their 4th enrollment on 3-18-2013 (the trial's 330th enrollment). 

Congratulations to Dr. Lawrence Wechsler (PI), Jennifer Oakley, (coordinator), and the rest of the team at the University of Pittsburgh Medical Center for their 8th enrollment on 3-15-2013 (the trial's 329th enrollment). 

Congratulations to Ryan Snider, (coordinator), and the rest of the team at the Stanford University for their 4th enrollment on 3-5-2013 (the trial's 328th enrollment). 

February - 2013

Congratulations to Dr. Panayiotis Varelas (PI), Kathleen Wilson, (coordinator), and the rest of the team at the University of Leipzig for their 12th enrollment on 2-28-2013 (the trial's 327th enrollment). 

Congratulations to Dr. Carsten Hobohm (PI), Daniela Urban, (coordinator), and the rest of the team at the University of Leipzig for their 3rd enrollment on 2-28-2013 (the trial's 326th enrollment). 

Congratulations to Dr. David B. Seder (PI), Barbara McCrum, (coordinator), and the rest of the team at Maine Medical Center for their 6th enrollment on 2-25-2013 (the trial's 325th enrollment). 

Congratulations to Dr. Jack Jallo (PI), Pamela Tremarki, (coordinator), and the rest of the team at Thomas Jefferson University Hospital for their 10th enrollment on 2-24-2013 (the trial's 324th enrollment). 

Congratulations to Dr. Sagi Harnof (PI), Nina Lehvar, (coordinator), and the rest of the team at Chaim Sheba Medical Center for their 18th enrollment on 2-24-2013 (the trial's 323rd enrollment). 

Congratulations to Dr. Nevo Margalit (PI), Carmit Ben Harosh, Raneen Yanaky (coordinators), and the rest of the team at Sourasky Medical Center for their 5th enrollment on 2-24-2013 (the trial's 322nd enrollment). 

Congratulations to Dr. Michel Torbey (PI), April Spangler (coordinator), and the rest of the team at Ohio State University Medical Center for their 4th enrollment on 2-20-2013 (the trial's 321st enrollment). 

Congratulations to Dr. David Sinclair (PI), Monica Abdou (coordinator), and the rest of the team at Montreal Neurological Institute at McGill University for their 3rd enrollment on 2-20-2013 (the trial's 320th enrollment). 

Congratulations to Dr. George Lopez (PI), Chad Tremont (coordinator), and the rest of the team at The University of Texas, Houston for their 16th enrollment on 2-19-2013 (the trial's 319th enrollment). 

Congratulations to Dr. Stanley Tuhrim (PI), Sandra Augustine (coordinator), and the rest of the team at Mount Sinai Hospital for their 3rd enrollment on 2-17-2013 (the trial's 318th enrollment). 

Congratulations to Dr. Sayona John (PI), Terry Cole, Fumie Kita (coordinators), and the rest of the team at Rush University for their 21st enrollment on 2-17-2013 (the trial's 317th enrollment). 

Congratulations to Dr. Paul Vespa (PI), Courtney Real, Nathan Stein (coordinators), and the rest of the team at UCLA for their 6th enrollment on 2-16-2013 (the trial's 316th enrollment). 

Congratulations to Dr. Guy Rosenthal (PI), Alex Furmanov (coordinator), and the rest of the team at Hadassah Hebrew University Hospital for their 3rd enrollment on 2-14-2013 (the trial's 315th enrollment). 

Congratulations to Dr. W. David Freeman (PI), Sothear Luke (coordinator), and the rest of the team at Mayo Clinic Jacksonville for their 4th enrollment on 2-11-2013 (the trial's 314th enrollment). 

Congratulations to Dr. Nevo Margalit (PI), Carmit Ben Harosh (coordinator), and the rest of the team at Sourasky Medical Center Tel Aviv for their 4th enrollment on 2-7-2013 (the trial's 313th enrollment). 

Congratulations to Dr. Laszlo Csiba (PI), Katalin Szabó (coordinator), and the rest of the team at the University of Debrecen for their 3rd enrollment on 2-5-2013 (the trial's 312th enrollment). 

Congratulations to Dr. Laszlo Szapary (PI), Peter Csecsei (coordinator), and the rest of the team at the University of Pecs for their 2nd enrollment on 2-5-2013 (the trial's 311th enrollment). 

Congratulations to Dr. David Greer (PI), Janet Halliday (coordinator), and the rest of the team at Yale University for their 2nd enrollment on 2-3-2013 (the trial's 310th enrollment). 

January - 2013

Congratulations to Dr. Jody Leonardo (PI), Mary Hartney, Jenna McAdoo (coordinators), and the rest of the team at the University of Buffalo for their 4th enrollment on 1-31-2013 (the trial's 309th enrollment). 

Congratulations to Dr. Sayona John (PI), Terry Cole, Fumie Kita (coordinators), and the rest of the team at Rush University for their 20th enrollment on 1-30-2013 (the trial's 308th enrollment). 

Congratulations to Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at University of Alabama at Birmingham for their 4th enrollment on 1-28-2013 (the trial's 307th enrollment). 

Congratulations to Dr. Thomas Mirsen (PI), Christine Beswick (coordinator), and the rest of the team at Cooper University Hospital for their 1st enrollment on 1-20-2013 (the trial's 306th enrollment). 

Congratulations to Dr. Lawrence Wechsler (PI), Julia Billigen (coordinator), and the rest of the team at The University of Pittsburgh Medical Center for their 7th enrollment on 1-17-2013 (the trial's 305th enrollment). 

Congratulations to Dr. Jack Jallo (PI), Pamela Tremarki (coordinator), and the rest of the team at Thomas Jefferson University Hospital for their 9th enrollment on 1-16-2013 (the trial's 304th enrollment). 

Congratulations to Dr. Fuat Arikan (PI), Alba Paris (coordinator), and the rest of the team at Vall d'Hebron University Hospital for their 6th enrollment on 1-16-2013 (the trial's 303rd enrollment). 

Congratulations to Dr. Robert Hoesch (PI), Julie Martinez (coordinator), and the rest of the team at the University of Utah for their 10th enrollment on 1-15-2013 (the trial's 302nd enrollment). 

Congratulations to Dr. Gisele Sampaio Silva (PI), Raul Valiente, and Dirceu Regis (coordinators), and the rest of the team at Hospital Sao Paolo UNIFESP for their 2nd enrollment on 1-10-2013 (the trial's 301st enrollment). 

Congratulations to Dr. Panayiotis Varelas (PI), Kathleen Wilson (coordinator), and the rest of the team at Henry Ford Health System for their 11th enrollment on 1-6-2013 (the trial's 300th enrollment). 

Congratulations to Dr. Laszlo Szapary (PI), Peter Bukovics (coordinator), and the rest of the team at the University of Pecs for their 1st enrollment on 1-3-2013 (the trial's 299th enrollment). 

See prior year enrollments

Intraventricular hemorrhage (IVH) is sudden bleeding into the ventricular system of the brain, often the result of severe ICH. This complication of hemorrhagic stroke has a mortality rate of 60-80% and only about 10% of patients recover with a good outcome.

Dec-2011

Congratulations again to Dr. Venkatesh Aiyagari (PI), Maureen Hillmann (coordinator), and the rest of the team at University of Illinois at Chicago for their 4th enrollment on 12-30-2011 (the trial's 191st enrollment). 

Congratulations again to Dr. Opeolu Adeoye (PI), Becky Reinert (coordinator), and the rest of the team at University of Cincinnati for their 5th enrollment on 12-22-2011 (the trial's 190th enrollment). 

Congratulations again to Dr. George Lopez (PI), Kari Langford (coordinator), and the rest of the team at University of Texas, Houston for their 6th enrollment on 12-21-2011 (the trial's 189th enrollment). 

Congratulations again to Dr. Sagi Harnof (PI), Yulia Wasserman (coordinator), and the rest of the team at Chaim Sheba medical Center for their 10th enrollment on 12-15-2011 (the trial's 188th enrollment). 

Congratulations again to Dr. Robert Hoesch (PI), Julie Martinez (coordinator), and the rest of the team at University of Utah for their 7th enrollment on 12-7-2011 (the trial's 187th enrollment). 

Congratulations again to Dr. Venkatesh Aiyagari (PI), Maureen Hillmann (coordinator), and the rest of the team at University of Illinois at Chicago for their 3rd enrollment on 12-6-2011 (the trial's 186th enrollment).

Congratulations again to Dr. Paul Vespa (PI), Maria Fillipou and Maria Etchepare (coordinators), and the rest of the team at University of California, Los Angeles for their 4th enrollment on 11-24-2011 (the trial's 184th enrollment).

Congratulations again to Dr. David Ledoux (PI), Oleg Rivkin (coordinator), and the rest of the team at Northshore, Long Island for their 4th enrollment on 11-21-2011 (the trial's 183rd enrollment). 

Congratulations again to Dr. Sayona John (PI), Terry Cole (coordinator), and the rest of the team at Rush University for their 13th enrollment on 11-19-2011 (the trial's 182nd enrollment).

Congratulations again to Dr. Thomas Kerz (PI) and the rest of the team at University of Mainz for their 3rd enrollment on 11-18-2011 (the trial's 181st enrollment). 

Congratulations again to Dr. Deitmar Schneider (PI), Rita Lachmund and Daniela Urban (coordinators), and the rest of the team at University of Leipzig for their 1st enrollment on 11-17-2011 (the trial's 180th enrollment). 

Congratulations again to Dr. Sagi Harnof (PI), Yulia Wasserman and Tali Kimchi (coordinators), and the rest of the team at Chaim Sheba Medical Center for their 9th enrollment on 11-17-2011 (the trial's 179th enrollment).

Congratulations again to Dr. Harold Adams (PI), Heena Olalde (coordinator), and the rest of the team at University of Iowa for their 3rd enrollment on 11-12-2011 (the trial's 178th enrollment).  

Congratulations again to Dr. Lawrence Wechsler (PI), Julia Billigen(coordinator), and the rest of the team at University of Pittsburgh Medical Center for their 4th enrollment on 11-8-2011 (the trial's 177th enrollment).  

Congratulations again to Dr. Sayona John (PI), Terry Cole (coordinator), and the rest of the team at Rush University for their 12th enrollment on 11-3-2011 (the trial's 176th enrollment).

Oct 2011

Congratulations again to Dr. Sven Poli (PI), Perdita Beck (coordinator), and the rest of the team at University of Heidelberg for their 4th enrollment on 10-28-2011 (the trial's 175th enrollment).  

Congratulations again to Dr. Jean Louis Caron (PI), Anne Leonard(coordinator), and the rest of the team at University of Texas, San Antonio for their 8th enrollment on 10-20-2011 (the trial's 174th enrollment).  

Congratulations to Dr. Agnieszka Ardelt (PI), Cedric McKoy (coordinator), and the rest of the team at University of Chicago for their 1st enrollment on 10-15-2011 (the trial's 173rd enrollment). 

Congratulations again to Dr. Jean Louis Caron (PI), Anne Leonard(coordinator), and the rest of the team at University of Texas, San Antonio for their 7th enrollment on 10-14-2011 (the trial's 172nd enrollment).

Sep 2011

Congratulations again to Dr. Thorsten Steiner (PI), Sven Poli (Co-PI)Perdita Beck (coordinator), and the rest of the team at University of Heidelberg for their 3nd enrollment on 9-28-2011 (the trial's 171st enrollment).  

Congratulations again to Dr. Thorsten Steiner (PI), Sven Poli (Co-PI)Perdita Beck (coordinator), and the rest of the team at University of Heidelberg for their 2nd enrollment on 9-22-2011 (the trial's 170th enrollment).  

Congratulations again to Dr. Christopher Loftus (PI), Emerson Clement (coordinator), and the rest of the team at Temple University for their 3rd enrollment on 9-21-2011 (the trial's 169th enrollment).  

Congratulations again to Dr. Stephan Mayer (PI), Noeleen Ostapkovich (coordinator), and the rest of the team at Columbia University for their 3rd enrollment on 9-19-2011 (the trial's 168th enrollment).  

Congratulations again to Dr. Michael Reinert (PI), Ralph Schaer (coordinator), and the rest of the team at University Hospital Inselspital, Bern for their 2nd enrollment on 9-19-2011 (the trial's 167th enrollment).  

Congratulations again to Dr. Paul Vespa (PI), Maria Fillipou and Maria Etchepare (coordinators), and the rest of the team at University of California, Los Angeles for their 3rd enrollment on 9-17-2011 (the trial's 166th enrollment). 

Congratulations again to Dr. Robert Hoesch (PI), Julie Martinez (coordinator), and the rest of the team at University of Utah for their 6th enrollment on 9-16-2011 (the trial's 165th enrollment). 

Congratulations to Dr. Michael Reinert (PI), Ralph Schaer (coordinator), and the rest of the team at University Hospital Inselspital, Bern for their 1st enrollment on 9-16-2011 (the trial's 164th enrollment).  

Congratulations again to Dr. Geoge Lopez (PI), Kari Langford (coordinator), and the rest of the team at University of Texas, Houston for their 5th enrollment on 9-9-2011 (the trial's 163th enrollment).  

Congratulations again to Dr. Sayona John (PI), Terry Cole (coordinator), and the rest of the team at Rush University for their 11th enrollment on 9-4-2011 (the trial's 162nd enrollment). 

Congratulations again to Dr. Sagi Harnof (PI), Yulia Wasserman (coordinator), and the rest of the team at Chaim Sheba Medical Center for their 8th enrollment on 9-1-2011 (the trial's 161st enrollment).

>> 2012 Enrollments

Enrollment Summary as of 31-Dec-12:

  • Total Enrollment - 298
    • International - 70
      • Israel - 22
      • Germany - 17
      • Spain - 10
      • Canada - 6
      • Switzerland - 4
      • Brazil - 3
      • United Kingdom - 5
      • Hungary - 3
    • USA - 228

December-2012

Congratulations to Dr. Harold Adams (PI), Heena Olalde (coordinator), and the rest of the team at the University of Iowa for their 8th enrollment on 12-31-2012 (the trial's 298th enrollment). 

Congratulations to Dr. Paul Camarata (PI), Dan Lewis (coordinator), and the rest of the team at Kansas University Medical Center for their 2nd enrollment on 12-31-2012 (the trial's 297th enrollment). 

Congratulations to Dr. David B. Seder (PI), Barbara McCrum (coordinator), and the rest of the team at Maine Medical Center for their 5th enrollment on 12-22-2012 (the trial's 296th enrollment). 

Congratulations to Dr. David Greer (PI), Janet Halliday (coordinator), and the rest of the team at Yale University for their 1st enrollment on 12-20-2012 (the trial's 295th enrollment). 

Congratulations to Dr. Sagi Harnof (PI), Nina Lehvar (coordinator), and the rest of the team at Chaim Sheba Medical Center for their 17th enrollment on 12-19-2012 (the trial's 294th enrollment). 

Congratulations to Dr. Michel Torbey (PI), April Spangler (coordinator), and the rest of the team at Ohio State University Medical Center for their 3rd enrollment on 12-17-2012 (the trial's 293rd enrollment). 

Congratulations to Dr. Diedrik Bulters (PI), Martina Brown (coordinator), and the rest of the team at the University of Southampton Hospital for their 4th enrollment on 12-13-2012 (the trial's 292nd enrollment). 

Congratulations to Dr. Gisele Sampaio Silva (PI), Raul Valiente (coordinator), and the rest of the team at Hospital Sao Paulo Universidade Federal de Sao Paulo/UNIFESP for their 1st enrollment on 12-12-2012 (the trial's 291st enrollment). 

Congratulations to Dr. Kevin Cockroft (PI), Deborah Hoffman (coordinator), and the rest of the team at Penn State Hershey Medical Center for their 4th enrollment on 12-11-2012 (the trial's 290th enrollment). 

November-2012 

Congratulations to Dr. Wendy Ziai (PI), Mirinda White (coordinator), and the rest of the team at Johns Hopkins University for their 10th enrollment on 11-29-2012 (the trial's 289th enrollment). 

Congratulations to Dr. Pedro Telles Cougo Pinto (PI), Rodrigo Barbosa Cerantola (coordinator), and the rest of the team at Hospital de Clinicas de Ribeirao Preto for their 1st enrollment on 11-28-2012 (the trial's 288th enrollment). 

Congratulations to Dr. Ann Helms (PI), Emon Das, Ashley Farrow-Schmidt (coordinators), and the rest of the team at the Medical College of Wisconsin for their 2nd enrollment on 11-20-2012 (the trial's 287th enrollment). 

Congratulations to Dr. Thomas Kerz (PI), and the rest of the team at The University of Mainz for their 5th enrollment on 11-20-2012 (the trial's 286th enrollment). 

Congratulations to Dr. Carsten Hobohm (PI), Daniela Urban (coordinator), and the rest of the team at The University of Leipzig for their 2nd enrollment on 11-19-2012 (the trial's 285th enrollment). 

Congratulations to Dr. A. David Mendelow (PI), Andrea Hughes (coordinator), and the rest of the team at Newcastle General Hospital for their 1st enrollment on 11-15-2012 (the trial's 284th enrollment). 

Congratulations to Dr. Sayona John (PI), Terry Cole (coordinator), and the rest of the team at Rush University for their 19th enrollment on 11-13-2012 (the trial's 283rd enrollment). 

Congratulations to Perdita Beck (coordinator), and the rest of the team at University Heidelberg for their 5th enrollment on 11-8-2012 (the trial's 282nd enrollment). 

Congratulations to Dr. Thomas Kerz (PI) and the rest of the team at University of Mainz for their 4th enrollment on 11-7-2012 (the trial's 281st enrollment). 

October-2012 

Congratulations to  Dr. George Lopez (PI), Chad Tremont (coordinator), and the rest of the team at University of Texas, Houston for their 15th enrollment on 10-30-2012 (the trial's 280th enrollment). 

Congratulations to  Dr. E. Francois Aldrich (PI), Charlene Aldrich (coordinator), and the rest of the team at the University of Maryland for their 8th enrollment on 10-29-2012 (the trial's 279th enrollment). 

Congratulations to  Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at the University of Alabama at Birmingham for their 3rd enrollment on 10-26-2012 (the trial's 278th enrollment). 

Congratulations to  Dr. Jack Jallo (PI), Pamela Tremarki (coordinator), and the rest of the team at Thomas Jefferson University Hospital for their 8th enrollment on 10-26-2012 (the trial's 277th enrollment). 

Congratulations to  Dr. Laszlo Csiba (PI), Katalin Szabó (coordinator), and the rest of the team at The University of Debrecen for their 2nd enrollment on 10-26-2012 (the trial's 276th enrollment). 

Congratulations to  Dr. Opeolu Adeoye (PI), Becky Reinert (coordinator), and the rest of the team at The University of Cincinnati for their 7th enrollment on 10-22-2012 (the trial's 275th enrollment). 

Congratulations to  Dr. Sagi Harnof (PI), Tali Kimchi (coordinator), and the rest of the team at Chaim Sheba Medical Center for their 16th enrollment on 10-4-2012 (the trial's 274th enrollment). 

September-2012

Congratulations to  Dr. Lawrence Wechsler (PI), Julia Billigen (coordinator), and the rest of the team at University of Pittsburgh Medical Center for their 6th enrollment on 9-30-2012 (the trial's 273rd enrollment). 

Congratulations to  Dr. Pal Barzo (PI), Eniko Fako (coordinator), and the rest of the team at the University of Szeged for their 1st enrollment on 9-30-2012 (the trial's 272nd enrollment). 

Congratulations to  Dr. David B. Seder, MD (PI), Barbara McCrum (coordinator), and the rest of the team at Maine Medical Center for their 4th enrollment on 9-28-2012 (the trial's 271st enrollment). 

Congratulations to  Dr. Sayona John (PI), Terry Cole (coordinator), and the rest of the team at Rush University for their 18th enrollment on 9-28-2012 (the trial's 270th enrollment). 

Congratulations to  Dr. Alan Hoffer (PI), Valerie Cwiklinski (coordinator), and the rest of the team at Case-Western Reserve University Hospital for their 5th enrollment on 9-24-2012 (the trial's 269th enrollment). 

Congratulations to  Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at  University of Alabama at Birmingham for their 2nd enrollment on 9-19-2012 (the trial's 268th enrollment). 

Congratulations to  Dr. Wendy Ziai (PI), Mirinda White (coordinator), and the rest of the team at Johns Hopkins Hospital for their 9th enrollment on 9-18-2012 (the trial's 267th enrollment). 

Congratulations to  Dr. Harold Adams (PI), Heena Olalde (coordinator), and the rest of the team at University of Iowa for their 7th enrollment on 9-18-2012 (the trial's 266th enrollment). 

Congratulations to  Dr. Jack Jallo (PI), Pamela Tremarki (coordinator), and the rest of the team at Thomas Jefferson University Hospital for their 7th enrollment on 9-18-2012 (the trial's 265th enrollment). 

Congratulations to  Dr. Sayona John (PI), Terry Cole (coordinator), and the rest of the team at Rush University for their 14th enrollment on 9-15-2012 (the trial's 264th enrollment). 

Congratulations to  Dr. George Lopez (PI), Chad Tremont (coordinator), and the rest of the team at University of Texas, Houston for their 14th enrollment on 9-14-2012 (the trial's 263rd enrollment). 

Congratulations to  Dr. Mark Harrigan (PI), Lisa Nelson (coordinator), and the rest of the team at University of Alabama at Birmingham for their 1st enrollment on 9-14-2012 (the trial's 262nd enrollment). 

Congratulations to  Dr. Asma Moheet (PI), Felice Lin (coordinator), and the rest of the team at Cedars-Sinai Medical Center for their 5th and 6th enrollments on 9-9-2012 and 9-11-2012 (the trial's 260th and 261st enrollments). 

Congratulations to  Dr. Sagi Harnof (PI), Tali Kimchi (coordinator), and the rest of the team at Chaim Sheba Medical Center for their 15th enrollment on 9-9-2012 (the trial's 259th enrollment). 

Congratulations to  Dr. Qaisar Shah (PI), Karin Jonczak (coordinator), and the rest of the team at Abington Memorial Hospital for their 1st enrollment on 9-4-2012 (the trial's 258th enrollment). 

Congratulations to  Dr. George Lopez (PI), Chad Tremont (coordinator), and the rest of the team at University of Texas, Houston for their 13th enrollment on 9-4-2012 (the trial's 257th enrollment). 

August-2012

Congratulations to  Dr. George Lopez (PI), Chad Tremont (coordinator), and the rest of the team at University of Texas, Houston for their 12th enrollment on 8-30-2012 (the trial's 256th enrollment). 

Congratulations to Dr. Robert Hoesch (PI), Julie Martinez (coordinator), and the rest of the team at the University of Utah for their 9th enrollment on 8-27-2012 (the trial's 255th enrollment). 

Congratulations to Dr. Panos Varelas (PI), Kathleen Mays-Wilson (coordinator), and the rest of the team at Henry Ford Health System for their 10th enrollment on 8-19-2012 (the trial's 254th enrollment). 

Congratulations to Dr. Jean-Louis Caron (PI), Anne Leonard (coordinator), and the rest of the team at University of Texas, San Antonio for their 11th enrollment on 8-17-2012 (the trial's 253rd enrollment). 

Congratulations to Dr. George Lopez (PI), Chad Tremont (coordinator), and the rest of the team at University of Texas, Houston for their 10th and 11th enrollments on 8-10-2012 and 8-15-2012 (the trial's 251st and 252nd enrollments). 

Congratulations to Dr. Nevo Margalit (PI), Carmit Ben Harosh (coordinator), and the rest of the team at Sourasky Medical Center, Tel Aviv for their 3rd enrollment on 8-9-2012 (the trial's 250th enrollment). 

Congratulations to Dr. Paul Vespa (PI), Nathan Stein (coordinator), and the rest of the team at University of California, Los Angeles for their 5th enrollment on 8-3-2012 (the trial's 249th enrollment). 

July-2012

Congratulations to Dr. Ashis Tayal (PI), Melissa Tian (coordinator), and the rest of the team at Allegheny General Hospital for their 7th enrollment on 7-31-2012 (the trial's 248th enrollment). 

Congratulations to Dr. Paul Camarata (PI), Ellen Juvet and Nichole Hedberg (coordinators), and the rest of the team at Kansas University Medical Center for their 1st enrollment on 7-27-2012 (the trial's 247th enrollment). 

Congratulations to Dr. Opeolu Adeoye (PI), Becky Reinert (coordinator), and the rest of the team at University of Cincinnati for their 6th enrollment on 7-25-2012 (the trial's 246th enrollment). 

Congratulations to Dr. Sagi Harnof (PI), Tali Kimchi-Yakar (coordinator), and the rest of the team at Chaim Sheba Medical Center for their 14th enrollment on 7-16-2012 (the trial's 245th enrollment). 

Congratulations to Dr. Michel Torbey (PI), April Spangler (coordinator), and the rest of the team at Ohio State University Medical Center for their 2nd enrollment on 7-14-2012 (the trial's 244th enrollment). 

Congratulations to Dr. Diederik Bulters (PI), Martina Brown (coordinator), and the rest of the team at University of Southampton for their 3rd enrollment on 7-13-2012 (the trial's 243rd enrollment). 

June-2012

Congratulations to Dr. Kristi Tucker (PI), Sarah Vaughn (coordinator), and the rest of the team at Wake Forest University for their 3rd enrollment on 6-30-2012 (the trial's 242nd enrollment). 

Congratulations to Dr. Darren Lovick (PI), Meghan Freier (coordinator), and the rest of the team at St. Luke's Brain and Stroke Institute, Kansas City for their 1st enrollment on 6-29-2012 (the trial's 241st enrollment). 

Congratulations to Dr. David Ledoux (PI), Oleg Rivkin (coordinator), and the rest of the team at NorthShore Long Island for their 7th enrollment on 6-21-2012 (the trial's 240th enrollment). 

Congratulations to Dr. Ashis Tayal (PI), Melissa Tian (coordinator), and the rest of the team at Allegheny General Hospital for their 6th enrollment on 6-20-2012 (the trial's 239th enrollment).

Congratulations to Dr. Allan Hoffer (PI), Valerie Cwiklinski (coordinator), and the rest of the team at Penn State Hershey Medical Center for their 3rd enrollment on 6-20-2012 (the trial's 238th enrollment).

Congratulations to Dr. Kevin Cockroft (PI), Deborah Hoffman (coordinator), and the rest of the team at Penn State Hershey Medical Center for their 3rd enrollment on 6-17-2012 (the trial's 237th enrollment).

Congratulations to Dr. Laszlo Csiba (PI), Katalin Szabó (coordinator), and the rest of the team at University of Debrecen for their 1st enrollment on 6-15-2012 (the trial's 236th enrollment).

May-2012

Congratulations to Dr. Sayona John (PI), Terry Cole (coordinator), and the rest of the team at Rush University for their 16th enrollment on 5-30-2012 (the trial's 235th enrollment).

Congratulations to Dr. Diederik Bulters (PI), Martina Brown (coordinator), and the rest of the team at University of Southampton Hospital for their 2nd enrollment on 5-30-2012 (the trial's 234th enrollment). 

Congratulations to Dr. Wendy Ziai (PI), Mirinda Anderson White (coordinator), and the rest of the team at Johns Hopkins Hospital for their 8th enrollment on 5-25-2012 (the trial's 233rd enrollment). 

Congratulations to Dr. Sagi Harnof (PI), Shiri Fischler (coordinator), and the rest of the team at Chaim Sheba Medical Center for their 13th enrollment on 5-24-2012 (the trial's 232nd enrollment). 

Congratulations to Dr. E. Francois Aldrich (PI), Charlene Aldrich (coordinator), and the rest of the team at University of Maryland for their 7th enrollment on 5-18-2012 (the trial's 231st enrollment). 

Congratulations to Dr. Jody Leonardo (PI), Mary Hartney, Jenna McAdoo (coordinators), and the rest of the team at University of Buffalo for their 3rd enrollment on 5-18-2012 (the trial's 230th enrollment). 

Congratulations to Dr. David Ledoux (PI), Oleg Rivkin (coordinator), and the rest of the team at NorthShore Long Island for their 6th enrollment on 5-9-2012 (the trial's 229th enrollment). 

Congratulations to Dr. Andreas Luft (PI), Benjamin Hertler (coordinator), and the rest of the team at University of Zurich for their 2nd enrollment on 5-02-2012 (the trial's 228th enrollment). 

Apr-2012

Congratulations to Dr. George Lopez (PI), Kari Langford (coordinator), and the rest of the team at University of Texas, Houston for their 9th enrollment on 4-27-2012 (the trial's 227th enrollment). 

Congratulations to Dr. Fuat Arikan (PI), Alba Peña Paris (coordinator), and the rest of the team at Vall d'Hebron University Hospital, Barcelona for their 5th enrollment on 4-26-2012 (the trial's 226th enrollment).

Congratulations to Dr. Nevo Margalit (PI), Carmit Ben Harosh (coordinator), and the rest of the team at Sourasky Medical Center, Tel Aviv for their 2nd enrollment on 4-21-2012 (the trial's 225th enrollment).

Congratulations to Dr. David Sinclair (PI), Winnie Poon (coordinator), and the rest of the team at Montreal Neurological Institute at McGill University for their 2nd enrollment on 4-20-2012 (the trial's 224th enrollment).

Congratulations to Dr. Stanley Tuhrim (PI), Sandra Augustine (coordinator), and the rest of the team at Mount Sinai Hospital for their 2nd enrollment on 4-20-2012 (the trial's 223rd enrollment).

Congratulations to Dr. Harold Adams (PI), Heena Olalde (coordinator), and the rest of the team at University of Iowa for their 6th enrollment on 4-19-2012 (the trial's 222nd enrollment).

Congratulations to Dr. Sayona John (PI), Terry Cole (coordinator), and the rest of the team at Rush University for their 15th enrollment on 4-10-2012 (the trial's 221st enrollment).

Congratulations to Dr. Salvador Cruz-Flores (PI), Eve Holzemer (coordinator), and the rest of the team at St. Louis University for their 14th enrollment on 4-9-2012 (the trial's 220th enrollment).

Congratulations to Dr. Sayona John (PI), Terry Cole (coordinator), and the rest of the team at Rush University for their 14th enrollment on 4-9-2012 (the trial's 219th enrollment).

Congratulations to Dr. Michel Torbey (PI), April Spangler (coordinator), and the rest of the team at Ohio State University Medical Center for their 1st enrollment on 4-7-2012 (the trial's 218th enrollment). 

Congratulations to Dr. R. Scott Graham (PI), Shivani Desai (coordinator), and the rest of the team at Virginia Commonwealth University for their 4th enrollment on 4-5-2012 (the trial's 217th enrollment). 

Congratulations to Dr. Ziad El-Zammar (PI), Iulia Movileanu (coordinator), and the rest of the team at SUNY Upstate Medical Center for their 3rd enrollment on 4-1-2012 (the trial's 216th enrollment). 

Mar-2012

Congratulations to Dr. George Lopez (PI), Kari Langford (coordinator), and the rest of the team at University of Texas, Houston for their 8th enrollment on 3-30-2012 (the trial's 215th enrollment). 

A special congratulations to Dr. Pedro-Cougo Pinto (PI) and the rest of the team at Hospital de Clinicas de Ribeirao Preto for their 1st enrollment on 3-14-2012 (the trial's 214th enrollment). This marks the very first enrollment in the trial from our Brazilian collaborators!

Congratulations to Dr. Sagi Harnof (PI), Yulia Wasserman, Tali Kimchi (coordinators), and the rest of the team at Chaim Sheba Medical Center for their 12th enrollment on 3-12-2012 (the trial's 213th enrollment). 

Congratulations to Dr. Andreas Luft (PI), Benjamin Hertler (coordinator), and the rest of the team at University of Zurich for their 1st enrollment on 3-07-2012 (the trial's 212th enrollment). 

Congratulations to Dr. George Lopez (PI), Kari Langford (coordinator), and the rest of the team at University of Texas, Houston for their 7th enrollment on 3-06-2012 (the trial's 211th enrollment). 

Congratulations to Dr. Jack Jallo (PI), Meghan Wakefield (coordinator), and the rest of the team at Thomas Jefferson University Hospital for their 6th enrollment on 3-06-2012 (the trial's 210th enrollment). 

Congratulations to Dr. Lawrence Wechsler (PI), Julia Billigen (coordinator), and the rest of the team at University of Pittsburgh for their 5th enrollment on 3-02-2012 (the trial's 209th enrollment). 

Feb-2012

Congratulations to Dr. Jean-Louis Caron (PI), Anne Leonard (coordinator), and the rest of the team at University of Texas, San Antonio for their 10th enrollment on 2-20-2012 (the trial's 208th enrollment). 

Congratulations to Dr. S. Alan Hoffer (PI), Valerie Cwiklinski (coordinator), and the rest of the team at Case-Western Reserve University Hospital for their 2nd enrollment on 2-18-2012 (the trial's 207th enrollment). 

Congratulations to Dr. David Ledoux (PI), Oleg Rivkin (coordinator), and the rest of the team at NorthShore Long Island for their 5th enrollment on 2-16-2012 (the trial's 206th enrollment). 

Congratulations to Dr. Sagi Harnof (PI), Yulia Wasserman (coordinator), and the rest of the team at Chaim Sheba Medical Center for their 11th enrollment on 2-15-2012 (the trial's 205th enrollment). 

Congratulations to Dr. Harold Adams (PI), Heena Olalde (coordinator), and the rest of the team at University of Iowa for their 5th enrollment on 2-9-2012 (the trial's 204th enrollment). 

Congratulations to Dr. William Freeman (PI), Alexa Richie (coordinator), and the rest of the team at Mayo Clinic, Jacksonville for their 3rd enrollment on 2-3-2012 (the trial's 203rd enrollment). 

Jan-2012

Congratulations to Dr. Christos Lazaridis (PI), Marc Lapointe (coordinator), and the rest of the team at Medical University of South Carolina for their 4th enrollment on 1-28-2012 (the trial's 202nd enrollment). 

Congratulations to Dr. Ashis Tayal (PI), Melissa Tian (coordinator), and the rest of the team at Allegheny General Hospital for their 5th enrollment on 1-24-2012 (the trial's 201st enrollment). 

Congratulations to Dr. Agnieszka Ardelt (PI), Cedric McKoy (coordinator), and the rest of the team at University of Chicago for their 2nd enrollment on 1-22-2012 (the trial's 200th enrollment). 

Congratulations again to Dr. David B. Seder (PI), Barbara McCrum (coordinator), and the rest of the team at Maine Medical Center for their 3rd enrollment on 22-Jan-2011 (the trial's 199th enrollment)

Congratulations again to Dr. Jean-Louis Caron (PI), Anne Leonard (coordinator), and the rest of the team at University of Texas, San Antonio for their 9th enrollment on 1-19-2012 (the trial's 198th enrollment). 

Congratulations again to Dr. Robert Hoesch (PI), Julie Martinez (coordinator), and the rest of the team at University of Utah for their 8th enrollment on 1-13-2012 (the trial's 196th enrollment). 

Congratulations again to Dr. Panayiotis Varelas (PI), Kathleen Mays-Wilson (coordinator), and the rest of the team at Henry Ford Health System for their 9th enrollment on 10-Jan-2011 (the trial's 195th enrollment). 

Congratulations again to Dr. David B. Seder (PI), Barbara McCrum (coordinator), and the rest of the team at Maine Medical Center for their 2nd enrollment on 5-Jan-2011 (the trial's 194th enrollment). 

Congratulations again to Dr. R. Scott Graham (PI), Dr. Randall Merchant (coordinator), and the rest of the team at Virginia Commonwealth University for their 3rd enrollment on 5-Jan-2011 (the trial's 193rd enrollment). 

Congratulations again to Dr. Fuat Arikan (PI), Alba Peña Paris (coordinator), and the rest of the team at Vall d'Hebron University Hospital, Barcelona for their 4th enrollment on 4-Jan-2011 (the trial's 192nd enrollment). This was the first enrollment of the new year!

See prior year enrollments

24-hour BIOS Cell Phone:  (410) 736-1368 (pre-randomization medical review)

24-hour Surgical Center Pager:  (773)-845-6145 (pre-randomization surgical review)

VISION EDC (case form) Website: http://bios.preludedynamics.com/vision

NIHSS/mRS Certification Courses:  http://clear-3.trainingcampus.net (requires separate log-in)

 

Protocol Title:  Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage, Phase III (CLEAR III)

Protocol Number:  IVH06

Current Version:  Version 3.0 / Last Revised 22-Mar-2011

  

Study Drug:  Alteplase® (recombinant tissue plasminogen activator), donated by Genentech Inc.

Study Design: multicenter, international, double-blind, placebo-controlled, randomized, parallel group

Primary Aim: determine if rapid removal of IVH clot with low-dose rtPA improves Modified Rankin Scores (0-3) at 6 Months as compared to subjects treated with best medical care alone

 

FDA IND Number:  BB-IND# 8523, submitted 28-July-1999

Sponsor: Daniel F. Hanley, MD (Head of Brain Injury Outcomes at Johns Hopkins)

Primary Funding: National Institute of Neurologic Disorders & Stroke (NINDS), an NIH institute (Collaborative Grant)

 

Target Enrollment:  500 patients (250 in each arm)

First Patient:  20-September, 2009  

Expected Completion:  Dec-2014 (for last enrollment), Dec-2015 (for last-patient-last visit)

Sites:  Approximately 70 across US, Canada, UK, Germany, Hungary, Brazil, Israel

 

NCT Registration Number:  NCT00784134

 

CLEAR Study App:  Android, Apple iOS