Guyane at DSMB Oct11Attendees for the Dec-2011 CLEAR III Coordinators' Webinar received a special holiday treat: Gayane Yenokyan from the Hopkins Biostatistics Center presented a preliminary analysis of the MISTIE-II outcomes data. In her information-packed review, Gayane explored the relationships between the various outcomes measures (Modified Rankin, SIS, Barthel, NIHSS) and made some very interesting findings. Also this month, Mark Macek, one of the site managers at the BIOS Coordinating Center, gave us an update on CLEAR-III enrollment and Natalie Ullman offerred to "Lets Make a Deal" with an exciting new way to simplify the enrollment process.

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Neurocritical Care Society Podcast on MISTIE III

For the November 2019 episode of the Neurocritical Care Society Podcast Series, Dr. Fawaz Al-Mufti was joined by Drs. Daniel Hanley and Issam Awad to discuss the results of the MISTIE III trial.  Read More

Dan Hanley Named Deputy Director of Johns Hopkins ICTR

Dr. Daniel Hanley, director of the BIOS Division, has been named the Deputy Director for Support and Innovation in Multicenter Trials at the Johns Hopkins Institute for Clinical and Translational Research.  Read More

MISTIE III: ‘A Big Step in the Right Direction’

The Journal of NeuroInterventional Surgery reports that though the MISTIE III trial did not reach its primary endpoint of improved functional outcome at one year, it did generate a wealth of high-quality data that provide invaluable insight into this devastating disease.  Read More

Recent Publications

Surgical performance determines functional outcome benefit in the MISTIE procedure.
Awad IA, Polster SP, Carrión-Penagos J, et al. Neurosurgery. 2019;84(6):1157-68.

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Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial.
Hanley DF, Thompson RE, Rosenblum M, et al. Lancet. 2019;393(10175):1021-32.

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Enhancing the informed consent process using shared decision making and consent refusal data from the CLEAR III trial.
Porter AL, Ebot J, Lane K, et al. Neurocritical Care. 2019 September 30.

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Intensive blood pressure reduction and perihematomal edema expansion in deep intracerebral hemorrhage.
Leasure AC, Qureshi AI, Murthy SB, et al. Stroke. 2019;50(8):2016-22.

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