Guyane at DSMB Oct11Attendees for the Dec-2011 CLEAR III Coordinators' Webinar received a special holiday treat: Gayane Yenokyan from the Hopkins Biostatistics Center presented a preliminary analysis of the MISTIE-II outcomes data. In her information-packed review, Gayane explored the relationships between the various outcomes measures (Modified Rankin, SIS, Barthel, NIHSS) and made some very interesting findings. Also this month, Mark Macek, one of the site managers at the BIOS Coordinating Center, gave us an update on CLEAR-III enrollment and Natalie Ullman offerred to "Lets Make a Deal" with an exciting new way to simplify the enrollment process.

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BIOS News

European Stroke Organisation

Professor Hanley presented the main results of the MISTIE-III trial, an RCT testing minimally invasive catheter evacuation of intracerebral haematoma, aided by local infiltration of alteplase (up to 9 x 1mg doses, 8h apart) with the aim of decreasing clot size to 15 mL or less, against standard medical management.  Read More

The Lancet

Acute stroke due to supratentorial intracerebral haemorrhage is associated with high morbidity and mortality. Open craniotomy haematoma evacuation has not been found to have any benefit in large randomised trials. We assessed whether minimally invasive catheter evacuation followed by thrombolysis (MISTIE), with the aim of decreasing clot size to 15 mL or less, would improve functional outcome in patients with intracerebral haemorrhage.  Read More

EurekAlert! The Global Source for Science News

Aggressive clearance key to best outcome after a brain hemorrhage. MISTIE III trial confirms need to remove at least 70 percent of an intracerebral clot.  Read More

Recent Publications

Neurocrit Care. 2018 Jan 2
The Incidence of Catheter Tract Hemorrhage and Catheter Placement Accuracy in the CLEAR III Trial
Müller A, Mould WA, Freeman WD2, McBee N, Lane K, Dlugash R, Thompson R, Nekoovaght-Tak S, Madan V1, Ali H, Stadnik A, Awad I, Hanley D, Ziai WC; CLEAR investigators.

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Int J Stroke. 2018 Jan;13(1):11-23
Fibrinolytic for treatment of intraventricular hemorrhage: A meta-analysis and systematic review
Baker AD, Rivera Perla KM, Yu Z, Dlugash R, Avadhani R, Mould WA, Ziai W, Thompson RE, Staykov D, Hanley DF

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Neurology. 2017 Oct 10;89(15):1553-1560
CSF inflammatory response after intraventricular hemorrhage
Fam MD, Zeineddine HA, Eliyas JK, Stadnik A, Jesselson M, McBee N, Lane K, Cao Y, Wu M, Zhang L, Thompson RE, John S, Ziai W, Hanley DF, Awad IA; CLEAR III Trial Investigators

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J Magn Reson Imaging. 2017 Aug 9
Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage
Zeineddine HA, Girard R, Cao Y, Hobson N, Fam MD, Stadnik A, Tan H, Shen J, Chaudagar K, Shenkar R, Thompson RE, McBee N, Hanley D, Carroll T, Christoforidis GA, Awad IA

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