Dr. Issam Awad, Co-Chairman and head of the CLEAR-III Surgical Center, recently made a presentation to the neurosurgeons and neurointensivists in this trial that you do not want to miss! Dr. Awad updated us on the latest surgical findings from the trial and how they impact the management of patients.
On the ICP Management form, there's a requirement to record the highest and lowest blood pressure within a 4-hour period. The determination of what is the highest and what is the lowest pressure in that period is based on mean arterial pressure (MAP). At UCLA, our system calculates MAP with an algorithm that doesn't completly agree with the equation MAP=((2xDBP)+SBP)/3, so I created an Excel spreadsheet to help identify the highest/lowest pressure.
[UPDATED 15-Nov] The Data Safety Monitoring Board (DSMB) for the CLEAR III clinical trial met today in both a closed session (to review unblinded data on the first 100 patients without the management team being present) and an open session where they asked questions of the project management and biostatistics teams from the BIOS Coordinating Center at Johns Hopkins. The official letter and a copy of the minutes have now been released and are attached below.