CLEAR INTRAVENTRICULAR HEMORRHAGE TRIAL

Does faster clot removal give better patient outcomes in IVH?

ZERO!

Last enrollment was #4500 at Henry Ford Hospital on 14-Jan-2015

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Welcome USC - Keck School of Medicine!

The CLEAR-III World Cup Competition

World Cup ChampionsJuly 1st is the start of the 4th fiscal year for the CLEAR-III trial (the first patient enrolled in Sep-2009). And this year we are introducing a new friendly competition called the CLEAR-III World Cup. Similar to international soccer competitions, regional groups of 3 to 5 clinical sites will be organized into teams. The teams will score points based on achieving certain performance goals such as having a randomization, resolving queries promptly, or completing a patient visit within the expected visit window.

The idea for this unique and exciting competition came from from one of the BIOS Reading Center staff, Sam Tak. Sam has created a wonderful new opportunity to enhance internal collaboration at sites and to foster camaraderie among the trial sites. Of course, we'll use our VISION-EDC system to track each teams scores on a real-time basis.

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CLEAR-III and MISTIE-ICES Open House

To all CLEAR III and MISTIE-ICES collaborators and guests,

You are invited to attend an open house for the CLEAR III and MISTIE‐ICES clinical trials to be held during the American Association of Neurological Surgeons (AANS) Meeting 2012 in Miami, Florida, USA.  

Monday, April 16, 2012 beginning at 5:30pm

Surfcomber Hotel – Miami South Beach (1/2 mile walk from the Convention Center)
1717 Collins Avenue
Miami Beach, Florida 33139
(LongBoard Room)

Refreshments will be served.

Please note that we cannot support any travel needs.

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CLEAR trial goes mobile - New Android & iOS App

CLEAR III App home screen on Apple iPhoneAnnouncing our new CLEAR III clinical trial app for the Android and Apple iOS mobile platforms! Now, right on your cellphone or tablet, you can review protocol information, get contact numbers, and even have the exhibits to show a patient during an outcomes assessment. The information is downloaded to your phone upon your first visit so afterwards you do not have to be online; the app will work even if you are not connected to the Internet.

Some of the tools that are available include:

Randomization - a quick link to the VISION EDC database and a review of the randomization process, including a helpful list of the minimum requirements for adaptive randomization to function properly.

Emergency Contact Numbers - who to call and a link to dial the number or generate an email.

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Bedside worksheets Updated - Redoux

Perfection can be an elusive goal, but one we are always pursuing here at the coordinating center. After our recent update of the bedside worksheets, someone found another obscure error. It's minor but to eliminate any potential confusion, we've corrected it anyway. A new version of the worksheets is now available for download.

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200th Patient Enrolled in CLEAR-III

BIOS (Johns Hopkins' Brain Injury Outcomes clinical trial coordinating center) is thrilled to announce the CLEAR III consortium reached an important milestone today: enrollment in the CLEAR III trial has reached 200 patients! That means we are now 40% of the way to our goal of enrolling 500 patients by the end of 2014. At this rate, we are on target to complete enrollment six months or more ahead of schedule, something that will be a major accomplishment for this international study! What a great team of investigators and coordinators we have!!!

Congratulations to Dr. Agnieszka Ardelt (principal investigator), Cedric McKoy (coordinator), and the rest of the team at University of Chicago for enrolling patient #4200 today. As the treatment is blinded, we don't know whether this patient received tPA or the placebo, but after only 3 doses both the IIIrd and IVth ventricles are now open and his Modified Graeb score has dropped from 15 to 7, definitely an improved prognosis for this still critically-ill patient after experiencing a 30cc intracerebral hematoma that expanded into a large intraventricular hemorrhage.

We update the patient-by-patient enrollment information each week. Also, you can read the Quarterly Assessment of Performance (QAP) report, where we discuss the various metrics being followed in this trial and the tremendous performance of the approximately 70 sites participating in the CLEAR III intraventricular hemorrhage trial.

Another notable milestone: the results of the closely-related MISTIE II trial in intracerebral hematoma will be presented by Dr. Daniel Hanley at the International Stroke Conference in New Orleans on February 1st. Check the MISTIE study blog for details.

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Brain Injury Outcomes

Johns Hopkins University
1550 Orleans Street
CRB-II, 3M50 South
Baltimore, MD 21231 USA
Office:   (410) 614-6996
Fax: (410) 502-7869
 
24-Hr: (410) 736-1368
Google Visualization API Sample
Last updated: 16-Dec-2015
CLEAR-III Enrollment Graph
CLEAR 3 Enrollment Graph
Last Updated: 16-Jan-2015